Epidemiology of thoracic aortic dissection
Top Cited Papers
- 21 December 2010
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Cardiology
- Vol. 8 (2), 103-113
- https://doi.org/10.1038/nrcardio.2010.187
Abstract
Thoracic aortic dissection (TAD) is estimated to occur at a rate of 3-4 cases per 100,000 persons per year and is associated with a high mortality. Reported rates are probably underestimates of the true incidence of TAD because of difficulties in diagnosis. The incidence of TAD appears to have been increasing over time. TAD is most common in men and older individuals. Aortic dilatation is a well-established risk factor for TAD but is not a prerequisite; most ascending aortic dissections occur when aortic diameter is <5.5 cm. Although atherosclerosis and typical cardiovascular risk factors, such as hypertension and smoking, are associated with TAD, evidence supporting their direct causal role is lacking. Notably, diabetes mellitus is remarkably uncommon in patients with TAD. Other risk factors for TAD include inflammatory diseases, iatrogenic aortic injury, and drug use. Congenital cardiovascular defects, such as bicuspid aortic valve, and certain genetic syndromes, such as Marfan syndrome, are the genetic factors most commonly associated with TAD. Specific nonsyndromic genetic mutations in families and single nucleotide polymorphisms have also been identified as possible risk factors for TAD.Keywords
This publication has 122 references indexed in Scilit:
- Aortic dissection in young adults who abuse amphetaminesAmerican Heart Journal, 2010
- Risk of Aortic Root or Ascending Aorta Complications in Patients With Bicuspid Aortic Valve With and Without Coarctation of the AortaThe American Journal of Cardiology, 2009
- Mutation ofACTA2gene as an important cause of familial and nonfamilial nonsyndromatic thoracic aortic aneurysm and/or dissection (TAAD)Human Mutation, 2009
- Aortic size in acute type A dissection: implications for preventive ascending aortic replacementEuropean Journal of Cardio-Thoracic Surgery, 2009
- Mutations in Smooth Muscle Alpha-Actin (ACTA2) Cause Coronary Artery Disease, Stroke, and Moyamoya Disease, Along with Thoracic Aortic DiseaseAmerican Journal of Human Genetics, 2009
- Dissection of the aorta in Turner syndrome: two cases and review of 85 cases in the literatureJournal of Medical Genetics, 2007
- A single nucleotide polymorphism in the matrix metalloproteinase 9 gene (−8202A/G) is associated with thoracic aortic aneurysms and thoracic aortic dissectionThe Journal of Thoracic and Cardiovascular Surgery, 2006
- Comparison of aortic dissection in patients with and without Marfan's syndrome (results from the International Registry of Aortic Dissection)The American Journal of Cardiology, 2004
- Reduced penetrance and variable expressivity of familial thoracic aortic aneurysms/dissectionsThe American Journal of Cardiology, 1998
- Aortic dissection in women <40 years of age and the unimportance of pregnancyThe American Journal of Cardiology, 1994