Effect of Computed Tomography Scanning Parameters on Gold Nanoparticle and Iodine Contrast
- 1 August 2012
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Investigative Radiology
- Vol. 47 (8), 475-481
- https://doi.org/10.1097/rli.0b013e3182562ab9
Abstract
Purpose Gold nanoparticles (gold-NPs) have lately been proposed as alternative contrast agents to iodine-based contrast agents (iodine-CA) for computed tomography (CT) angiography. The aims of this study were to confirm an appropriate environment in which to evaluate such novel contrast agents, to investigate the comparative contrast of iodine-CA versus gold-NP, and to determine optimal scanning parameters for gold-NP. Materials and Methods Three different clinical scanners were used to acquire CT images. A range of concentrations (10 mM to 1.5 M) of gold-NP and iodine-CA were scanned with varying x-ray tube voltages and currents, reconstruction kernels, protocols, and scanner models. The different environments investigated were air, water, and water with a bone simulant (Ca3(PO4)2). Regression coefficients were derived from the attenuation values plotted against concentration and compared for statistical significance using t values. Results As expected, contrast was linearly related to concentrations up to 500 to 1000 mM, depending on the conditions used, whereupon a plateau of 3000 Hounsfield units was reached. Attenuation was significantly different depending on the environment used (air, water, or water and bone simulant). Contrast is dependent on the x-ray tube voltage used, with the contrast produced from iodine-CA sharply declining with increasing voltage, whereas the contrast of gold-NP varied less with tube voltage but was maximal at 120 kV in water with bone simulant. Current, reconstruction kernels, protocols, and scanner model had less effect on contrast. Conclusion Water with a bone simulant is a preferable environment for evaluating novel cardiac CT contrast agents. Relative iodine-CA versus gold-NP contrast is dependent on the scanning conditions used. Optimal scanning conditions for gold-NP will likely use an x-ray tube voltage of 120 kV.Keywords
This publication has 27 references indexed in Scilit:
- Computed Tomography in Color: NanoK‐Enhanced Spectral CT Molecular ImagingAngewandte Chemie-International Edition, 2010
- Atherosclerotic Plaque Composition: Analysis with Multicolor CT and Targeted Gold NanoparticlesRadiology, 2010
- Dual Energy CT of the ChestInvestigative Radiology, 2010
- X-ray computed tomography contrast agents prepared by seeded growth of gold nanoparticles in PEGylated dendrimerNanotechnology, 2010
- Bombesin functionalized gold nanoparticles show in vitro and in vivo cancer receptor specificityProceedings of the National Academy of Sciences of the United States of America, 2010
- Gold nanoparticles functionalized by gadolinium–DTPA conjugate of cysteine as a multimodal bioimaging agentBioorganic & Medicinal Chemistry Letters, 2010
- Detecting Vascular Biosignatures with a Colloidal, Radio-Opaque Polymeric NanoparticleJournal of the American Chemical Society, 2009
- Nanocrystal Core High-Density Lipoproteins: A Multimodality Contrast Agent PlatformNano Letters, 2008
- A dual CT‐MR dendrimer contrast agent as a surrogate marker for convection‐enhanced delivery of intracerebral macromolecular therapeutic agentsContrast Media & Molecular Imaging, 2008
- Gold nanoparticles: a new X-ray contrast agentThe British Journal of Radiology, 2006