Olfactory and Oral Manifestations of COVID‐19: Sex‐Related Symptoms—A Potential Pathway to Early Diagnosis
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Open Access
- 16 June 2020
- journal article
- research article
- Published by Wiley in Otolaryngology -- Head and Neck Surgery
- Vol. 163 (4), 722-728
- https://doi.org/10.1177/0194599820934380
Abstract
The coronavirus disease 2019 (COVID-19) pandemic poses a threat to global health. Early diagnosis is an essential key to limit the outbreak of the virus. Case series, study conducted between March 25, 2020, and April 15, 2020. Ambulatory, nonhospitalized patients who were quarantined in a designated hotel for COVID-19 patients and were recruited by an advertisement at the hotel. In total, 140 patients participated in a web-based questionnaire assessing initial symptoms of common viral diseases, olfactory and taste functions, xerostomia, and orofacial pain. A total of 58 men and 70 women participated. Initial symptoms were cough (59.4%), weakness (47.7%), myalgia (46.9%), fever (42.2%), headache (40.6%), impaired sense of smell (38.3%), impaired sense of taste (32.8%), sore throat (26.6%), runny nose (26.6%), and nasal congestion (22.7%). All symptoms were more frequent among women; however, only runny nose was statistically significant (P = .018). The most common combination of symptoms was cough and weakness (37.5%). A total of 25.8% reported olfactory and taste dysfunctions in the absence of other symptoms. In a comparison between the sexes, cough and runny nose were the most common combination in women (P = .018). A total of 38.3% of patients reported olfactory dysfunction as an initial symptom. Anosmia and facial pain were more common among women (P < .001 and P = .01, respectively), and 56% of patients reported xerostomia. A considerable number of patients presented with olfactory and oral disorders. Interestingly, women presented with a different cluster of symptoms than men, which may suggest a new clinical approach to diagnosing COVID-19 disease.Keywords
This publication has 29 references indexed in Scilit:
- Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, ChinaJAMA Neurology, 2020
- COVID-19 and the consequences of isolating the elderlyThe Lancet Public Health, 2020
- World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19)International Journal of Surgery, 2020
- Clinical features of patients infected with 2019 novel coronavirus in Wuhan, ChinaThe Lancet, 2020
- Epidemiology, Genetic Recombination, and Pathogenesis of CoronavirusesTrends in Microbiology, 2016
- Smell and taste disordersFacial Plastic Surgery Clinics of North America, 2004
- Association Between Interleukin‐8 Concentration in Nasal Secretions and Severity of Symptoms of Experimental Rhinovirus ColdsClinical Infectious Diseases, 1998
- Prevalence of perceived symptoms of dry mouth in an adult Swedish population ‐ relation to age, sex and pharmacotherapyCommunity Dentistry and Oral Epidemiology, 1997
- Signs and symptoms in common coldsEpidemiology and Infection, 1993
- Infraorbital Nerve Dehiscence: The Anatomic Cause of Maxillary Sinus “Vacuum Headache”?Otolaryngology -- Head and Neck Surgery, 1992