Successful treatment of myasthenia gravis with tacrolimus
- 19 December 2001
- journal article
- case report
- Published by Wiley in Muscle & Nerve
- Vol. 25 (1), 111-114
- https://doi.org/10.1002/mus.10018
Abstract
Tacrolimus (FK‐506) is a calcium‐calcineurin inhibitor, successfully used in transplant recipients. We report the successful use of tacrolimus as a single immunosuppressant in a patient who had developed myasthenia gravis (MG) during interferon alpha treatment. In this case, the coexistence of hepatitis C and type 2 diabetes mellitus contraindicated the use of both steroids and azathioprine, and cyclosporine A, although effective, had induced renal failure. Tacrolimus proved to be effective in the treatment of MG, was not significantly hepatotoxic, and was less nephrotoxic than cyclosporine. © 2002 John Wiley & Sons, Inc. Muscle Nerve 25: 111–114, 2002Keywords
This publication has 21 references indexed in Scilit:
- Development of insulin-dependent diabetes mellitus in a patient with chronic hepatitis C during therapy with interferon-αEuropean Journal of Gastroenterology & Hepatology, 2001
- A NOVEL MANAGEMENT STRATEGY OF STEROID-FREE IMMUNOSUPPRESSION AFTER LIVER TRANSPLANTATION: EFFICACY AND SAFETY OF TACROLIMUS AND MYCOPHENOLATE MOFETILTransplantation, 2001
- Conversion of renal transplant recipients from cyclosporin to low-dose tacrolimus for refractory rejectionTransplant International, 1998
- A COMPARISON OF TACROLIMUS (FK506) AND CYCLOSPORINE FOR IMMUNOSUPPRESSION AFTER CADAVERIC RENAL TRANSPLANTATION1Transplantation, 1997
- FK506 Prevents Induction of Rat Experimental Autoimmune Myasthenia GravisJournal of Autoimmunity, 1997
- CorrespondenceJournal of the Neurological Sciences, 1996
- Anti-gabaergic neuron autoantibodies in a patient with stiff-man syndrome and ataxiaJournal of the Neurological Sciences, 1996
- Development of myasthenia gravis during interferon-alpha treatment for anti-HCV positive chronic hepatitis.Journal of Neurology, Neurosurgery & Psychiatry, 1996
- Myasthenia GravisNew England Journal of Medicine, 1994
- Detection of islet cell specificity of monoclonal islet cellsurface antibodies by means of double-staining immunofluorescenceActa Histochemica, 1988