Respiratory tract colonization with Pseudomonas aeruginosa in cystic fibrosis: Correlations between anti‐Pseudomonas aeruginosa antibody levels and pulmonary function
- 1 January 1991
- journal article
- Published by Wiley in Pediatric Pulmonology
- Vol. 10 (2), 92-100
- https://doi.org/10.1002/ppul.1950100210
Abstract
Chronic Pseudomonas aeruginosa respiratory tract colonization in patients with cystic fibrosis is associated with development of antibodies to the organism. In contrast to the protection usually afforded by humoral immunity to a bacterial pathogen, the immune response to P. aeruginosa may help perpetuate infection and contribute to pulmonary damage in cystic fibrosis. To determine if specific anti‐P. aeruginosa antibody levels correlated with pulmonary dysfunction, we measured antibodies to seven P. aeruginosa serotypes, and correlated the geometric mean titer with pulmonary function tests. Patients were divided into groups without P. aeruginosa colonization (n = 20), with recent colonization (n = 20), and with chronic colonization (n = 60). Noncolonized patients had normal pulmonary function or mild obstructive lung disease, and low anti‐P. aeruginosa titers. Pulmonary function tests in recently colonized patients were not different from those of noncolonized patients, but antibody titers were higher. Following colonization FEV1 declined and titers increased rapidly. Patients with chronic colonization had worse pulmonary function and higher titers, but while the former were stable the latter gradually increased. An inverse correlation was found between anti‐P. aeruginosa titer and FVC, FEV1, and FEF25–75 (P < 0.001) in these patients; age was not a factor. The strong correlation between severity of lung disease and anti‐P. aeruginosa titer demonstrates that an exaggerated immune response to P. aeruginosa is associated with pulmonary damage in patients with cystic fibrosis. Pediatr Pulmonol 1991; 10:92–100.Keywords
This publication has 30 references indexed in Scilit:
- Pulmonary function and clinical course in patients with cystic fibrosis after pulmonary colonization with Pseudomonas aeruginosaThe Journal of Pediatrics, 1990
- Complement receptor expression on neutrophils at an inflammatory site, the Pseudomonas-infected lung in cystic fibrosis.JCI Insight, 1989
- Intravenous immune globulin treatment of pulmonary exacerbations in cystic fibrosisThe Journal of Pediatrics, 1989
- Serum IgG antibodies in patients with cystic fibrosis with early Pseudomonas aeruginosa infection.Archives of Disease in Childhood, 1987
- Hemophilus Influenzae Type B Disease in Children Vaccinated with Type B Polysaccharide VaccineNew England Journal of Medicine, 1986
- Serum antibodies to Pseudomonas aeruginosa in cystic fibrosis.Archives of Disease in Childhood, 1986
- Development of enzyme linked immunosorbent assay (ELISA) to detect antibodies to Pseudomonas aeruginosa cell surface antigens in sera of patients with cystic fibrosis.Journal of Clinical Pathology, 1986
- Cystic fibrosis pseudomonas opsonins. Inhibitory nature in an in vitro phagocytic assay.JCI Insight, 1981
- 125I-Clq-binding and specific antibodies as indicators of pulmonary disease activity in cystic fibrosisThe Journal of Pediatrics, 1981
- Immune Complexes in Cystic FibrosisBMJ, 1975