Is Tourette's syndrome an autoimmune disease?
- 1 June 2002
- journal article
- review article
- Published by Springer Science and Business Media LLC in Molecular Psychiatry
- Vol. 7 (5), 437-445
- https://doi.org/10.1038/sj.mp.4000972
Abstract
We provide a review of recent research findings which support the involvement of autoimmunity in childhood-onset tic disorders, in particular the presence of antineuronal autoantibodies, D8/17 B lymphocyte overexpression, a marker of chorea associated with streptococcal infection, and possible beneficial effects of immunomodulatory intervention. One of the most controversial areas in this field is the validity of the proposed PANDAS concept. Some researchers have delineated a putatively unique subgroup of patients, from the spectrum of illness encompassing Tourette's syndrome and obsessive-compulsive disorder (OCD), whose tics and obsessive-compulsive symptoms are shown to arise in response to beta-hemolytic streptococcal infections. They designated it by the term pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS). Herein we additionally present pros and cons concerning the concept of PANDAS. Finally, recommendations for future research directions are given.Keywords
This publication has 61 references indexed in Scilit:
- Genome scan for linkage to Gilles de la Tourette syndromeAmerican Journal of Medical Genetics, 1999
- Increased plasma kynurenine and its relationship to neopterin and tryptophan in Tourette's syndromePsychological Medicine, 1996
- Tissue Distribution of Antigen(s) Defined by Monoclonal Antibody D8/17 Reacting with B Lymphocytes of Patients with Rheumatic Heart DiseaseClinical Immunology and Immunopathology, 1994
- The Role of Autoantibodies in Autoimmune DiseaseAnnual Review of Immunology, 1993
- QUINOLINIC ACID AND KYNURENINE PATHWAY METABOLISM IN INFLAMMATORY AND NON-INFLAMMATORY NEUROLOGICAL DISEASEBrain, 1992
- Tourette's Syndrome Treated with ACTH and Prednisone: Report of Two CasesJournal of Child and Adolescent Psychopharmacology, 1992
- ASPECTS OF ANKYLOSING SPONDYLITISRheumatology, 1991
- Blood serotonin and tryptophan in Tourette syndromeAmerican Journal of Medical Genetics, 1990
- Whole blood serotonin and tryptophan levels in Tourette's disorder: Effects of acute and chronic clonidine treatmentLife Sciences, 1984
- Corticosteroid therapy and tourette syndromeAnnals of Neurology, 1979