Curcumin reduces indomethacin‐induced damage in the rat small intestine
- 9 March 2007
- journal article
- Published by Wiley in Journal of Applied Toxicology
- Vol. 27 (6), 551-560
- https://doi.org/10.1002/jat.1235
Abstract
Non‐steroidal anti‐inflammatory drugs (NSAIDs) are commonly used in clinical medicine. Their utility is, however, often limited by the adverse effects they produce in the gastrointestinal tract. Oxidative stress has been shown to occur in the small intestine in response to the oral administration of indomethacin, an NSAID commonly used in toxicity studies. In view of this, the effect of curcumin, an agent with anti‐oxidant properties, was evaluated on indomethacin‐induced small intestinal damage in a rat model. Rats were pretreated with various doses of curcumin (20 mg kg−1, 40 mg kg−1 and 80 mg kg−1) before administering indomethacin at 20 mg kg−1. Various parameters of oxidative stress and the extent of small intestinal damage produced by indomethacin, with and without pretreatment with curcumin, were measured. Macroscopic ulceration was found to occur in the small intestine in response to indomethacin. The viability of enterocytes from indomethacin‐treated animals was significantly lower than those from control animals. Drug‐induced oxidative stress was also evident as seen by increases in the levels of malondialdehyde and protein carbonyl and in activities of pro‐oxidant enzymes such as myeloperoxidase and xanthine oxidase in indomethacin‐treated rats. Concomitant decreases were seen in the activities of the antioxidant enzymes catalase and glutathione peroxidase in these animals. Pretreatment with curcumin was found to ameliorate these drug‐induced changes. Thus, curcumin appears to hold promise as an agent that can potentially reduce NSAID‐induced small intestinal damage. Copyright © 2007 John Wiley & Sons, Ltd.Keywords
This publication has 45 references indexed in Scilit:
- Anti‐apoptotic effects of curcumin on photosensitized human epidermal carcinoma A431 cellsJournal of Cellular Biochemistry, 2004
- Effects of indomethacin on energy metabolism in rat jejunal tissue in vivoClinical Science, 2002
- Diarylheptanoids with Free Radical Scavenging and Hepatoprotective Activity in vitro from Curcuma longaPlanta Medica, 2001
- Dextran Sulfate Sodium-Induced Colonic Histopathology, but not Altered Epithelial Ion Transport, Is Reduced by Inhibition of Phosphodiesterase ActivityThe American Journal of Pathology, 2000
- Gastric mucosal contraction and vascular injury induced by indomethacin precede neutrophil infiltration in the rat.Gut, 1996
- Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitroNature, 1995
- Diminution of singlet oxygen-induced DNA damage by curcmin and related antioxidantsMutation Research - Reviews in Mutation Research, 1994
- Importance of local versus systemic effects of non-steroidal anti-inflammatory drugs in increasing small intestinal permeability in man.Gut, 1991
- Lipid fluidity and composition of intestinal microvillus membranes isolated from rats of different agesBiochimica et Biophysica Acta (BBA) - Biomembranes, 1984
- Lipid composition and fluidity of rat enterocyte basolateral membranes regional differencesBiochimica et Biophysica Acta (BBA) - Biomembranes, 1984