Placental pathology in women with gestational diabetes
- 1 April 2008
- journal article
- research article
- Published by Wiley in Acta Obstetricia et Gynecologica Scandinavica
- Vol. 87 (4), 403-407
- https://doi.org/10.1080/00016340801908783
Abstract
Background. The aim of this study was to investigate pathologic differences of the placenta in pregnancies complicated by gestational diabetes compared to non‐diabetic pregnancies. Methods. Forty singleton pregnancies complicated by gestational diabetes were recruited and compared to 40 consecutive normal pregnancies. A pathologist, blinded to all clinical data, reviewed all histological samples of the placentas. The histological assessment was carried out with regard to the following aspects: fetal vessel thrombosis, villous immaturity, chorangiosis, presence of nucleated fetal red blood cells (NFRBCs), ischemia, infarction, presence of hydropic or avascular villi, lymphohistiocytic villitis and villous fibrinoid necrosis. Results. The presence of degenerative lesions such as fibrinoid necrosis and vascular lesions like chorangiosis was apparent, mainly in the diabetes group. Villous immaturity and the presence of NFRBC as an indication of chronic fetal hypoxia were significantly increased in the placentas of women with diabetes compared with the control group. Fetal/placental weight ratio was significantly lower in the diabetic group. Conclusion. Histological abnormalities were observed more frequently in the diabetic placentas compared to the controls. These findings support the hypothesis that impaired placental function is one of the main reasons for the increased frequency of fetal complications in diabetic pregnancies.This publication has 14 references indexed in Scilit:
- Period of gestational diabetes mellitus diagnosis and maternal and fetal morbidityActa Obstetricia et Gynecologica Scandinavica, 2005
- Placental Pathology in Women with Type 1 Diabetes and in a Control Group with Normal and Large-for-Gestational-Age InfantsPlacenta, 2003
- New score indicating placental vascular resistanceActa Obstetricia et Gynecologica Scandinavica, 2003
- Placental weight to birthweight ratio is increased in mild gestational glucose intolerancePlacenta, 1997
- Maternal Diseases Complicating Pregnancy: Diabetes, Tumors, Preeclampsia, Lupus AnticoagulantPublished by Springer Science and Business Media LLC ,1995
- Placental Protein Distribution in Maternal Diabetes Mellitus: An Immunocytochemical StudyPediatric Pathology, 1989
- Morphological findings in placentae of insulin-dependent diabetic patients treated with continuous subcutaneous insulin infusion (CSII)Placenta, 1987
- Villous structure in different parts of the cotyledon in placentas of insulin‐dependent diabetic womenActa Obstetricia et Gynecologica Scandinavica, 1984
- Changes in red blood cell oxygen transport in diabetic pregnancyAmerican Journal of Obstetrics and Gynecology, 1982
- WEIGHT RELATIONSHIPS IN PREGNANCYObstetrical & Gynecological Survey, 1968