Influencia de los factores clínicos y biográficos en la calidad de vida de las mujeres durante la quimioterapia adyuvante por cáncer de mama
- 31 October 2011
- journal article
- abstracts
- Published by Elsevier BV in Revista de Calidad Asistencial
- Vol. 26 (5), 299-305
- https://doi.org/10.1016/j.cali.2011.04.005
Abstract
Adjuvant chemotherapy affects the life of women with breast cancer in different ways. The aim of this work is to study the effect of adjuvant chemotherapy on the quality of their lives and the impact of their clinical and biographical characteristics. Women with breast cancer, candidates for adjuvant chemotherapy, participating in a randomised trial with non-pharmacological intervention (ClinicalTrials.gov Identifier: NCT00964522), completed the EORTC QOL-C30 and QOL-BR23 quality of life questionnaires before, in the middle, and at the end of the treatment. Fifty women completed the questionnaires. Overall health got worse over time (p=0.01). Physical functioning (p=0.0001) and body image (p=0.002) were the scales that deteriorated most, and asthenia (p=0.004), nausea/vomiting (p=0.05), and anorexia (p=0.025), were the symptoms with the largest temporary impact of the chemotherapy. Unemployed women had worse physical functioning (p=0.046) and role functioning (p=0.005). Older women had more diarrhoea (p=0.013). The most qualified women had a worse score in financial difficulties scale (p=0.034). Women with advanced stage (III) underwent more deterioration in the body image (p=0.001) and were more concerned about the future (p=0.006). Women treated with anthracycline and taxane also had a worse perspective of the future (p=0.02). Adjuvant chemotherapy deteriorates the quality of life of patients with breast cancer, basically in physical functioning and body image areas. Asthenia and gastrointestinal toxicity are the side effects that affect patients most. Women need support if they are older, unemployed, more educated, and have stage III breast cancer treated with anthracycline and taxane based chemotherapy.Keywords
This publication has 22 references indexed in Scilit:
- Long-term Prognostic Role of Functional Limitations Among Women With Breast CancerJNCI Journal of the National Cancer Institute, 2010
- Health-related quality of life in breast cancer patients: A bibliographic review of the literature from 1974 to 2007Journal of Experimental & Clinical Cancer Research, 2008
- Quality of life assessment in women with breast cancer: benefits, acceptability and utilizationHealth and Quality of Life Outcomes, 2007
- Side-effects of chemotherapy and quality of life in ovarian and breast cancer patientsCurrent Opinion in Obstetrics and Gynecology, 2006
- National Institutes of Health State-of-the-Science Conference Statement: Symptom Management in Cancer: Pain, Depression, and Fatigue, July 15-17, 2002JNCI Journal of the National Cancer Institute, 2003
- Factors affecting baseline quality of life in two international adjuvant breast cancer trialsBritish Journal of Cancer, 1998
- The European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-of-Life Instrument for Use in International Clinical Trials in OncologyJNCI Journal of the National Cancer Institute, 1993
- Measuring psychological and physical distress in cancer patients: structure and application of the Rotterdam Symptom ChecklistBritish Journal of Cancer, 1990
- Effect of peri-operative chemotherapy on the quality of life of patients with early breast cancerEuropean Journal of Cancer and Clinical Oncology, 1990
- Adjuvant chemotherapy for breast cancer: side effects and quality of life.BMJ, 1980