2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors
- 31 December 2010
- journal article
- Published by Elsevier BV in European Journal of Medicinal Chemistry
- Vol. 45 (12), 5958-5964
- https://doi.org/10.1016/j.ejmech.2010.09.062
Abstract
No abstract availableKeywords
This publication has 23 references indexed in Scilit:
- New insights into small‐molecule inhibitors of Bcr‐AblMedicinal Research Reviews, 2010
- Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological dataEuropean Journal of Medicinal Chemistry, 2009
- C6‐Unsubstituted Pyrazolo[3,4‐d]pyrimidines Are Dual Src/Abl Inhibitors Effective against Imatinib Mesylate Resistant Chronic Myeloid Leukemia Cell LinesChemMedChem, 2009
- Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidinesEuropean Journal of Medicinal Chemistry, 2008
- Structure-Based Optimization of Pyrazolo[3,4-d]pyrimidines as Abl Inhibitors and Antiproliferative Agents toward Human Leukemia Cell LinesJournal of Medicinal Chemistry, 2008
- Synthetic Src-Kinase Domain Inhibitors and Their Structural RequirementsAnti-Cancer Agents in Medicinal Chemistry, 2007
- Identification of a Novel Pyrazolo[3,4-d]pyrimidine Able To Inhibit Cell Proliferation of a Human Osteogenic Sarcoma in Vitro and in a Xenograft Model in MiceJournal of Medicinal Chemistry, 2007
- High throughput solubility measurement in drug discovery and developmentAdvanced Drug Delivery Reviews, 2007
- Inhibition of Bcr‐Abl Phosphorylation and Induction of Apoptosis by Pyrazolo[3,4‐d]pyrimidines in Human Leukemia CellsChemMedChem, 2007
- Pharmaceutical profiling in drug discoveryDrug Discovery Today, 2003