Walking impairment in patients with multiple sclerosis: exercise training as a treatment option
Open Access
- 1 November 2010
- journal article
- review article
- Published by Taylor & Francis Ltd in Neuropsychiatric Disease and Treatment
- Vol. 6 (1), 767-774
- https://doi.org/10.2147/ndt.s10480
Abstract
Abstract: Multiple sclerosis (MS) is a chronic disease of the central nervous system that culminates in the progression of physical and cognitive disability over time. Walking impairment is a ubiquitous feature of MS and a sentinel characteristic of the later or advanced stages of the disease. This paper presents a conceptual rationale along with empirical evidence for exercise training as a rehabilitation approach for managing walking impairment and improving walking function in persons with MS. Conceptually, MS is associated with a decrease in physical activity, which, in turn, can result in deconditioning across multiple domains of physiological functioning. The resulting deconditioning feeds back and further drives physical inactivity until a threshold is reached that likely initiates the progression of walking impairment in MS. Empirically, physical activity and exercise training have been associated with beneficial effects on walking function in persons with MS. This is based on cross-sectional, longitudinal, and experimental research that included diversity in the breadth of measures of walking, persons with MS, and exercise/physical activity characteristics. Of particular importance, future researchers might consider examining the combinatory effects of exercise training plus pharmacological agents on walking mobility in MS. Collectively, exercise training and physical activity might hold significant potential for the management of progressive mobility disability in MS.Keywords
This publication has 41 references indexed in Scilit:
- Lifestyle Physical Activity and Walking Impairment over Time in Relapsing-Remitting Multiple SclerosisAmerican Journal of Physical Medicine & Rehabilitation, 2011
- Accelerometry in persons with multiple sclerosis: Measurement of physical activity or walking mobility?Journal of the Neurological Sciences, 2010
- Symptoms and Physical Activity Among Adults With Relapsing-Remitting Multiple SclerosisJournal of Nervous & Mental Disease, 2010
- Exercise attenuates the clinical, synaptic and dendritic abnormalities of experimental autoimmune encephalomyelitisNeurobiology of Disease, 2009
- Effect of Exercise Training on Walking Mobility in Multiple Sclerosis: A Meta-AnalysisNeurorehabilitation and Neural Repair, 2008
- Effect of exercise training on quality of life in multiple sclerosis: a meta-analysisMultiple Sclerosis Journal, 2008
- Validity of physical activity measures in ambulatory individuals with multiple sclerosisDisability and Rehabilitation, 2006
- Physical activity and multiple sclerosis: a meta-analysisMultiple Sclerosis Journal, 2005
- Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequencesCurrent Opinion in Neurology, 2001
- 4‐Aminopyridine in multiple sclerosisNeurology, 1991