Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer
- 17 September 2010
- journal article
- Published by Springer Science and Business Media LLC in Cancer Microenvironment
- Vol. 4 (2), 141-154
- https://doi.org/10.1007/s12307-010-0052-5
Abstract
Experimental and epidemiological studies indicate a strong link between chronic inflammation and tumor progression. Human colorectal cancer (CRC), a major cause of cancer-related death in Western countries, represents a paradigm for this link. Key features of cancer-related inflammation in CRC are the activation of transcription factors (e.g. NF-κB, STAT3), the expression of inflammatory cytokines and chemokines (e.g. TNFα, IL-6, CCL2, CXCL8) as well as a prominent leukocyte infiltrate. While considerable evidence indicates that the presence of lymphocytes of adaptive immunity may positively influence patient survival and clinical outcome in CRC, the role of tumor-associated macrophages (TAM) and of other lymphoid populations (e.g. Th17, Treg) is still unclear. In this review we will summarize the different and controversial effects that TAM play in CRC-related inflammation and progression of disease. The characterization of the most relevant inflammatory pathways in CRC is instrumental for the identification of new target molecules that could lead to improved diagnosis and treatment.Keywords
This publication has 141 references indexed in Scilit:
- The role of chemokines in intestinal inflammation and cancerCurrent Opinion in Pharmacology, 2009
- The NF-κB/AKT-dependent Induction of Wnt Signaling in Colon Cancer Cells by Macrophages and IL-1βCancer Microenvironment, 2009
- The Tumor Microenvironment: The Making of a ParadigmCancer Microenvironment, 2009
- The role of inflammation in the pathogenesis of colorectal cancerCurrent Colorectal Cancer Reports, 2009
- Inflammation and Cancer: IL-6 and STAT3 Complete the LinkCancer Cell, 2009
- IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated CancerCancer Cell, 2009
- TGFβ in CancerCell, 2008
- Immune cells as mediators of solid tumor metastasisCancer and Metastasis Reviews, 2007
- Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult MiceCancer Cell, 2007
- Role of tumor-associated macrophages in tumor progression and invasionCancer and Metastasis Reviews, 2006