Retinal Oximetry in Primary Open-Angle Glaucoma
Open Access
- 1 August 2011
- journal article
- research article
- Published by Association for Research in Vision and Ophthalmology (ARVO) in Investigative Ophthalmology & Visual Science
- Vol. 52 (9), 6409-6413
- https://doi.org/10.1167/iovs.10-6985
Abstract
Purpose.: To determine whether retinal vessel oxygen saturation is affected in primary open-angle glaucoma (POAG) patients. Methods.: Retinal oxygen saturation in patients with POAG was measured in retinal vessels with a spectrophotometric retinal oximeter in darkness, and visual fields were obtained. Oxygen tension (Po 2) was calculated from oxygen saturation values. Statistical analysis was performed using Pearson's correlation and Student's t-test. Results.: Mean oxygen saturation in venules was higher in persons with poor visual fields (68% ± 4%, mean ± SD) than in those with good visual fields (62% ± 3%; P = 0.0018). The mean arteriovenous difference in oxygen saturation was lower in persons with poor visual fields (30% ± 4%, n = 9) than in those with good visual fields (37% ± 4%; P = 0.0003; n = 12). No correlation was found between saturation in retinal arterioles and visual field mean defect (n = 31; r = −0.16; P = 0.38). Oxygen saturation in retinal venules correlated positively with worsening visual field mean defect (r = 0.43; P = 0.015). Arteriovenous difference in oxygen saturation decreased significantly as the visual field mean defect worsened (r = −0.55; P = 0.0013). Mean Po 2 in venules was 38 ± 3 mm Hg. It was significantly higher in persons with poor visual field fields (40 ± 3 mm Hg) than in those with good visual fields (36 ± 2 mm Hg; P = 0.0016). Conclusions.: Deeper glaucomatous visual field defects are associated with increased oxygen saturation in venules and decreased arteriovenous difference in retinal oxygen saturation. The data suggest that oxygen metabolism is affected in the glaucomatous retina, possibly related to tissue atrophy.This publication has 39 references indexed in Scilit:
- Biomechanics of the optic nerve headExperimental Eye Research, 2009
- Endothelial dysfunction in glaucomaActa Ophthalmologica, 2009
- Blood flow in glaucomaCurrent Opinion in Opthalmology, 2005
- The effects of antiglaucoma and systemic medications on ocular blood flowProgress in Retinal and Eye Research, 2003
- The impact of ocular blood flow in glaucomaProgress in Retinal and Eye Research, 2002
- A comparison of ocular blood flow in untreated primary open-angle glaucoma and ocular hypertensionAmerican Journal of Ophthalmology, 1998
- Ocular haemodynamics in glaucoma associated with high myopia.International Ophthalmology, 1998
- Measurement of ocular blood flow velocity using colour doppler imaging in low tension glaucomaEye, 1995
- Color Doppler Analysis of Ocular Vessel Blood Velocity in Normal-tension GlaucomaAmerican Journal of Ophthalmology, 1994
- Ophthalmic artery flow velocity in glaucomatous and normal subjects.British Journal of Ophthalmology, 1993