Pathophysiology of cell phone radiation: oxidative stress and carcinogenesis with focus on male reproductive system
Open Access
- 22 October 2009
- journal article
- research article
- Published by Springer Science and Business Media LLC in Reproductive Biology and Endocrinology
- Vol. 7 (1), 114
- https://doi.org/10.1186/1477-7827-7-114
Abstract
Hazardous health effects stemming from exposure to radiofrequency electromagnetic waves (RF-EMW) emitted from cell phones have been reported in the literature. However, the cellular target of RF-EMW is still controversial. This review identifies the plasma membrane as a target of RF-EMW. In addition, the effects of RF-EMW on plasma membrane structures (i.e. NADH oxidase, phosphatidylserine, ornithine decarboxylase) and voltage-gated calcium channels are discussed. We explore the disturbance in reactive oxygen species (ROS) metabolism caused by RF-EMW and delineate NADH oxidase mediated ROS formation as playing a central role in oxidative stress (OS) due to cell phone radiation (with a focus on the male reproductive system). This review also addresses: 1) the controversial effects of RF-EMW on mammalian cells and sperm DNA as well as its effect on apoptosis, 2) epidemiological, in vivo animal and in vitro studies on the effect of RF-EMW on male reproductive system, and 3) finally, exposure assessment and dosimetry by computational biomodeling.Keywords
This publication has 98 references indexed in Scilit:
- Mobile Phone Radiation Induces Reactive Oxygen Species Production and DNA Damage in Human Spermatozoa In VitroPLOS ONE, 2009
- ODC1 Is a Critical Determinant of MYCN Oncogenesis and a Therapeutic Target in NeuroblastomaCancer Research, 2008
- Brain tumor epidemiology: Consensus from the Brain Tumor Epidemiology ConsortiumCancer, 2008
- Ca2+-dependent protein kinase C isoforms are critical to estradiol 17β-D-glucuronide-induced cholestasis in the ratHepatology, 2008
- Protein kinase C is an important signaling mediator associated with motility of intact sea urchin spermatozoaJournal of Experimental Biology, 2007
- Mechanism of short-term ERK activation by electromagnetic fields at mobile phone frequenciesBiochemical Journal, 2007
- Exposure to cell phone radiation up-regulates apoptosis genes in primary cultures of neurons and astrocytesNeuroscience Letters, 2007
- Effects of 1.8GHz radiofrequency field on DNA damage and expression of heat shock protein 70 in human lens epithelial cellsMutation Research, 2006
- Comparative Study of Cell Cycle Kinetics and Induction of Apoptosis or Necrosis after Exposure of Human Mono Mac 6 Cells to Radiofrequency RadiationRadiation Research, 2006
- Mechanisms of electromagnetic interaction with cellular systemsThe Science of Nature, 1992