Expression of the transcription factor Ets-1 is an independent prognostic marker for relapse-free survival in breast cancer
- 4 December 2002
- journal article
- research article
- Published by Springer Science and Business Media LLC in Oncogene
- Vol. 21 (55), 8506-8509
- https://doi.org/10.1038/sj.onc.1206040
Abstract
The transcription factor Ets-1 regulates the expression of several angiogenic and extracellular matrix remodeling factors, and might be implicated in disease progression of breast cancer. In the present study, the prognostic value of Ets-1 expression was assessed by quantitative real-time fluorescence RT–PCR in 123 sporadic primary breast cancer samples of patients with a median follow-up time of 62 months. Ets-1 expression levels correlated significantly with VEGF and PAI-1 in the same tissue. In univariate (P=0.0011) and multivariate (P=0.005) analyses, Ets-1 expression showed significant prognostic value for relapse-free survival. Ets-1 is a strong, independent predictor of poor prognosis in breast cancer. This seems – at least in part – to be attributable to its role in transcriptional regulation of factors involved in angiogenesis (VEGF), and extracellular matrix remodeling (PAI-1).Keywords
This publication has 16 references indexed in Scilit:
- Pooled Analysis of Prognostic Impact of Urokinase-Type Plasminogen Activator and Its Inhibitor PAI-1 in 8377 Breast Cancer PatientsJNCI Journal of the National Cancer Institute, 2002
- The Ets-1 transcription factor is up-regulated together with MMP 1 and MMP 9 in the stroma of pre-invasive breast cancerThe Journal of Pathology, 2001
- Ets target genes: past, present and futureOncogene, 2000
- Ets factors and regulation of the extracellular matrixOncogene, 2000
- Transcription factors and breast cancerEndocrine-Related Cancer, 1998
- Ets-1 regulates angiogenesis by inducing the expression of urokinase-type plasminogen activator and matrix metalloproteinase-1 and the migration of vascular endothelial cellsJournal of Cellular Physiology, 1996
- The Ets family of transcription factorsEuropean Journal of Biochemistry, 1993
- The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active.Proceedings of the National Academy of Sciences of the United States of America, 1985
- Tripartite structure of the avian erythroblastosis virus E26 transforming geneNature, 1983
- Nonparametric Estimation from Incomplete ObservationsJournal of the American Statistical Association, 1958