Although percutaneous needle biopsies are typically safe, there are possible musculoskeletal needle biopsy complications. Preoperative consultation with orthopaedic surgeons providing treatment is appropriate for radiologists performing percutaneous tumor biopsies because biopsy tracts need to be resected along with the specimens in cases of primary malignancy. Knowledge of compartmental anatomy may help avoid complications related to poorly planned or executed needle biopsies that may compromise the ability of the surgeon to perform a limb-sparing resection.