Compulsive Behaviors as Presenting Symptoms of Frontotemporal Dementia
- 1 December 1997
- journal article
- research article
- Published by SAGE Publications in Journal of Geriatric Psychiatry and Neurology
- Vol. 10 (4), 154-157
- https://doi.org/10.1177/089198879701000405
Abstract
Frontotemporal dementia (FTD) is a common neurodegenerative dementia syndrome. Compulsive behaviors frequently occur in FTD and may be presenting symptoms of this disorder. This study evaluated compulsive behaviors as presenting symptoms in 29 patients with FTD compared to 48 patients with Alzheimer's disease (AD) enrolled in the UCLA Alzheimer's Disease Center. The FTD patients met the Lund and Manchester criteria for FTD and had predominant frontal hypoperfusion on single-photon emission computer tomography neuroimaging. The AD patients met National Institute of Neurological and Communicative Disorders-Alzheimer's Disease and Related Disorders criteria for clinically probable AD. Compulsive behaviors occurred in 11 FTD patients (38%) versus 5 AD patients (10%) (χ2 = 6.73, P < .01). This difference persisted after controlling for the younger age of the FTD group. There was a range of compulsive behaviors, with the most frequent being repetitive checking activities. Compulsive behaviors are common presenting symptoms among FTD patients and may result from an inability to inhibit urges to perform compulsive movements from damage to frontal-striatal circuits.Keywords
This publication has 33 references indexed in Scilit:
- A study of the Lund‐Manchester research criteria for frontotemporal dementiaNeurology, 1997
- Can I trust you, doctor? The ethics of managed careJournal of Clinical Neuroscience, 1997
- Functional Magnetic Resonance Imaging of Symptom Provocation in Obsessive-compulsive DisorderArchives of General Psychiatry, 1996
- Frontotemporal dementia: a clinicopathological review of four postmortem studiesThe Journal of Neuropsychiatry and Clinical Neurosciences, 1996
- Systematic Changes in Cerebral Glucose Metabolic Rate After Successful Behavior Modification Treatment of Obsessive-Compulsive DisorderArchives of General Psychiatry, 1996
- Repetitive and compulsive behavior in frontal lobe degenerationsThe Journal of Neuropsychiatry and Clinical Neurosciences, 1994
- Functional Anatomy of Obsessive–Compulsive PhenomenaThe British Journal of Psychiatry, 1994
- Clinical and neuropathological criteria for frontotemporal dementia. The Lund and Manchester Groups.Journal of Neurology, Neurosurgery & Psychiatry, 1994
- Pick's disease versus Alzheimer's diseaseNeurology, 1993
- Kluver‐Bucy Syndrome in Pick diseaseNeurology, 1981