Dopamine Transporter (DAT1) and Dopamine Receptor D4 (DRD4) Genotypes Differentially Impact on Electrophysiological Correlates of Error Processing
Open Access
- 5 December 2011
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 6 (12), e28396
- https://doi.org/10.1371/journal.pone.0028396
Abstract
Recent studies as well as theoretical models of error processing assign fundamental importance to the brain's dopaminergic system. Research about how the electrophysiological correlates of error processing—the error-related negativity (ERN) and the error positivity (Pe)—are influenced by variations of common dopaminergic genes, however, is still relatively scarce. In the present study, we therefore investigated whether polymorphisms in the DAT1 gene and in the DRD4 gene, respectively, lead to interindividual differences in these error processing correlates. One hundred sixty participants completed a version of the Eriksen Flanker Task while a 26-channel EEG was recorded. The task was slightly modified in order to increase error rates. During data analysis, participants were split into two groups depending on their DAT1 and their DRD4 genotypes, respectively. ERN and Pe amplitudes after correct responses and after errors as well as difference amplitudes between errors and correct responses were analyzed. We found a differential effect of DAT1 genotype on the Pe difference amplitude but not on the ERN difference amplitude, while the reverse was true for DRD4 genotype. These findings are in line with predictions from theoretical models of dopaminergic transmission in the brain. They furthermore tie results from clinical investigations of disorders impacting on the dopamine system to genetic variations known to be at-risk genotypes.Keywords
This publication has 58 references indexed in Scilit:
- Associations between Dopamine D4 Receptor Gene Variation with Both Infidelity and Sexual PromiscuityPLOS ONE, 2010
- The DRD4 receptor Exon 3 VNTR and 5′ SNP variants and mRNA expression in human post‐mortem brain tissueAmerican Journal Of Medical Genetics Part B-Neuropsychiatric Genetics, 2010
- Dopamine Transporter (SLC6A3) Genotype Impacts Neurophysiological Correlates of Cognitive Response Control in an Adult Sample of Patients with ADHDNeuropsychopharmacology, 2010
- Genetic association studies of performance monitoring and learning from feedback: The role of dopamine and serotoninNeuroscience & Biobehavioral Reviews, 2010
- Multicenter Analysis of the SLC6A3/DAT1 VNTR Haplotype in Persistent ADHD Suggests Differential Involvement of the Gene in Childhood and Persistent ADHDNeuropsychopharmacology, 2009
- Dopamine DRD2 Polymorphism Alters Reversal Learning and Associated Neural ActivityJournal of Neuroscience, 2009
- Neural correlates of performance monitoring in adult patients with attention deficit hyperactivity disorder (ADHD)The World Journal of Biological Psychiatry, 2009
- Error processing in patients with Parkinson’s disease: the influence of medication stateJournal of Neural Transmission, 2008
- Error Processing in Huntington's DiseasePLOS ONE, 2006
- ERP correlates of impaired error monitoring in children with ADHDJournal of Neural Transmission, 2005