Bone resorption control of tooth eruption and root morphogenesis: Involvement of the receptor activator of NF‐κB (RANK)
- 26 October 2010
- journal article
- research article
- Published by Wiley in Journal of Cellular Physiology
- Vol. 226 (1), 74-85
- https://doi.org/10.1002/jcp.22305
Abstract
Activation of the receptor activator of NF‐κB (RANK) is a crucial step in osteoclastogenesis. Loss‐ and gain‐of‐function mutations in the Rank gene cause, respectively, osteopetrosis and several forms of extensive osteolysis. Tooth and alveolar bone alterations are associated with these pathologies but remain to be better characterized. The aim of the present study was to establish the tooth and alveolar bone phenotype of a transgenic mouse model of RANK over‐expression in osteoclast precursors. Early tooth eruption and accelerated tooth root elongation were observed subsequent to an increase in osteoclast numbers surrounding the tooth. The final root length appeared not to be affected by RANK over‐expression, but a significant reduction in root diameter occurred in both control and root‐morphogenesis‐defective Msx2 null mutant mice. These results indicate that root length is independent of the surrounding bone resorption activity. In contrast, root diameter is sensitive to the activity of alveolar bone osteoclasts. These data suggest that early eruption and thin root are phenotypic features that could be associated with extensive osteolytic pathologies. J. Cell. Physiol. 226: 74–85, 2010.Keywords
This publication has 54 references indexed in Scilit:
- Cellular and molecular basis of tooth eruptionOrthodontics & Craniofacial Research, 2009
- BMP4 signaling regulates formation of Hertwig’s epithelial root sheath during tooth root developmentCell and tissue research, 2008
- Human Osteoclast-Poor Osteopetrosis with Hypogammaglobulinemia due to TNFRSF11A (RANK) MutationsAmerican Journal of Human Genetics, 2008
- Human dental follicle cells acquire cementoblast features under stimulation by BMP-2/-7 and enamel matrix derivatives (EMD) in vitroCell and tissue research, 2007
- Paget's Disease of Bone and Genetic Disorders of RANKL/OPG/RANK/NF‐κB SignalingAnnals of the New York Academy of Sciences, 2006
- Idiopathic Hyperphosphatasia and TNFRSF11B Mutations: Relationships Between Phenotype and GenotypeJournal of Bone and Mineral Research, 2003
- Phenotypic Characterization of Early Onset Paget's Disease of Bone Caused by a 27-bp Duplication in the TNFRSF11A GeneJournal of Bone and Mineral Research, 2003
- Identification of a Novel Tandem Duplication in Exon 1 of the TNFRSF11A Gene in Two Unrelated Patients With Familial Expansile OsteolysisJournal of Bone and Mineral Research, 2003
- Behavior of epithelial root sheath during tooth root formation in porcine molars: TUNEL, TEM, and immunohistochemical studiesBrain Structure and Function, 2002
- Expansile Skeletal Hyperphosphatasia: A New Familial Metabolic Bone DiseaseJournal of Bone and Mineral Research, 2000