Evaluation of pathological changes in broilers during chronic aflatoxin (50 and 100 ppb) and clinoptilolite exposure
- 11 September 2004
- journal article
- clinical trial
- Published by Elsevier BV in Research in Veterinary Science
- Vol. 78 (1), 61-68
- https://doi.org/10.1016/j.rvsc.2004.06.006
Abstract
This study was conducted to evaluate the pathological changes in broilers fed a diet containing low-levels of aflatoxin (AF) and clinoptilolite (CLI) until 42 days of age. A total of 576 one-day-old Ross-308 type broiler chicks were treated with varying levels of AF and CLI (15 g kg−1). The gross and histopathological changes in the liver, kidneys, spleen, thymus and bursa of Fabricius were investigated and relative organ weights were calculated. Compared to controls, significant changes (P < 0.05), such as slight to moderate hydropic degeneration and/or fatty change (8 cases of 10), bile-duct hyperplasia (7 of 10) and periportal fibrosis (5 of 10), were found in chicks fed 100 ppb AF-containing diet. No gross–pathological changes were observed in any treatments. The addition of CLI to the 100 ppb AF-containing diet significantly decreased the number of affected broilers and/or the severity of lesions (hydropic degeneration and bile-duct hyperplasia) in the livers (P < 0.05). The addition of CLI to the AF-free diet did not produce any significant lesions compared with the controls.Keywords
This publication has 25 references indexed in Scilit:
- Effects of aflatoxin B1on the development of the bursa of Fabricius and blood lymphocyte acid phosphatase of the chickenBritish Poultry Science, 2003
- Biological suppression of aflatoxicosis in Japanese quail (Coturnix coturnix japonica) by dietary addition of yeast (Saccharomyces cerevisiae)Research in Veterinary Science, 2001
- Ameliorative effects of dietary clinoptilolite on pathological changes in broiler chickens during aflatoxicosisResearch in Veterinary Science, 2001
- Ameliorative effects of sodium bentonite on phagocytosis and Newcastle disease antibody formation in broiler chickens during aflatoxicosisResearch in Veterinary Science, 2000
- Effect of clinoptilolite on serum biochemical and haematological characters of broiler chickens during aflatoxicosisResearch in Veterinary Science, 2000
- Effect of clinoptilolite on performance of Japanese quail (Coturnix coturnix japonica) during experimental aflatoxicosisBritish Poultry Science, 1999
- The preventive effect of polyvinylpolypyrrolidone on aflatoxicosis in broilersAvian Pathology, 1998
- Effect of feeding clinoptilolite (zeolite) on the performance of three strains of laying hensBritish Poultry Science, 1997
- Aflatoxin adsorbent capacity of two Mexican aluminosilicates in experimentally contaminated chick dietsFood Additives & Contaminants, 1995
- Variations of clinical biochemical parameters of laying hens and broiler chickens fed aflatoxin‐containing feedAvian Pathology, 1994