Glucose-Triggered Drug Delivery from Borate Mediated Layer-by-Layer Self-Assembly
- 27 April 2010
- journal article
- Published by American Chemical Society (ACS) in ACS Applied Materials & Interfaces
- Vol. 2 (5), 1521-1527
- https://doi.org/10.1021/am100139j
Abstract
In this study, we report a novel approach for glucose-triggered anticancer drug delivery from the self-assembly of neutral poly(vinyl alcohol) (PVA) and chitosan. In the present study, we have fabricated multilayer thin film of PVA-borate and chitosan on colloidal particle (MF particle) and monitored the layer-by-layer growth using Zeta potential measurements. Formation of multilayer membrane on MF particle has been further characterized with transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM). Subsequently, disintegration of multilayer thin film and microcapsules was observed in presence of glucose. We investigated the disassembly of PVA-borate and chitosan self-assembly under CLSM and atomic force microscopy. These results suggest that this multilayer thin film is very efficient for encapsulation and release of DOX molecules above certain concentration of glucose (25 mM). This glucose-sensitive self-assembly is relevant for the application of anticancer therapeutic drug delivery.Keywords
This publication has 43 references indexed in Scilit:
- Layer-by-Layer Self-Assembly of Modified Hyaluronic Acid/Chitosan Based on Hydrogen BondingBiomacromolecules, 2009
- Dual Drug Delivery Microcapsules via Layer-by-Layer Self-AssemblyLangmuir, 2009
- Photonic crystal borax competitive binding carbohydrate sensing motifThe Analyst, 2009
- Salt-induced erosion of hydrogen-bonded layer-by-layer assembled filmsSoft Matter, 2009
- Encapsulation of Uncharged Water-Insoluble Organic Substance in Polymeric Membrane Capsules via Layer-by-Layer ApproachThe Journal of Physical Chemistry B, 2008
- Biorecognition through Layer-by-Layer Polyelectrolyte Assembly: In-Situ Hybridization on Living CellsBiomacromolecules, 2006
- Release of Plasmid DNA from Intravascular Stents Coated with Ultrathin Multilayered Polyelectrolyte FilmsBiomacromolecules, 2006
- Fabrication of Stable Hollow Capsules by Covalent Layer-by-Layer Self-AssemblyMacromolecules, 2003
- The morphology of layer-by-layer films of polymer/polyelectrolyte studied by atomic force microscopyNanotechnology, 2002
- Glucose catabolism in cancer cells: regulation of the type II hexokinase promoter by glucose and cyclic AMPFEBS Letters, 1996