Midtrimester Intra-Amniotic Sludge and the Risk of Spontaneous Preterm Birth
- 17 November 2011
- journal article
- research article
- Published by Georg Thieme Verlag KG in American Journal of Perinatology
- Vol. 28 (10), 815-820
- https://doi.org/10.1055/s-0031-1295638
Abstract
We examined the association between midtrimester intra-amniotic sludge and spontaneous preterm birth (PTB) in asymptomatic women undergoing amniocentesis. We performed a prospective cohort study of women having an amniocentesis for fetal karyotyping between 14 and 24 weeks’ gestation. Cervical length and the presence of amniotic sludge were assessed by transvaginal ultrasound. Amniotic fluid concentrations of matrix metalloproteinase-8, glucose and lactate were measured. Early (p < 0.01). Two women with combined dense amniotic sludge and short cervix delivered 4 and 10 weeks later (at 20 and 25 weeks, respectively) and had a higher median amniotic lactate concentration than controls (p < 0.05). A third woman with dense amniotic sludge at 15 weeks was diagnosed with a short cervix and an intra-amniotic infection at 22 weeks that was eradicated with intravenous antibiotics. Midtrimester dense amniotic sludge is associated with early PPROM and spontaneous PTB.Keywords
This publication has 7 references indexed in Scilit:
- The origin ofFusobacterium nucleatuminvolved in intra-amniotic infection and preterm birthThe Journal of Maternal-Fetal & Neonatal Medicine, 2011
- Clinical implication of intra‐amniotic sludge on ultrasound in patients with cervical cerclageUltrasound in Obstetrics & Gynecology, 2010
- Twenty percent of very preterm neonates (23-32 weeks of gestation) are born with bacteremia caused by genital MycoplasmasAmerican Journal of Obstetrics and Gynecology, 2008
- What is amniotic fluid ‘sludge’?Ultrasound in Obstetrics & Gynecology, 2007
- Clinical significance of the presence of amniotic fluid ‘sludge’ in asymptomatic patients at high risk for spontaneous preterm deliveryUltrasound in Obstetrics & Gynecology, 2007
- A sonographic short cervix as the only clinical manifestation of intra-amniotic infectionjpme, 2006
- The prevalence and clinical significance of amniotic fluid ‘sludge’ in patients with preterm labor and intact membranesUltrasound in Obstetrics & Gynecology, 2005