Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II
- 1 August 1992
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 358 (6388), 641-645
- https://doi.org/10.1038/358641a0
Abstract
Phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II is believed to control the transition from transcription initiation to elongation. The general transcription factor IIH (TFIIH) contains a kinase activity capable of phosphorylating this domain. Factors that promote the association of RNA polymerase II with the preinitiation complex stimulate this activity. The transcription factor IIE, which is required for the stable association of TFIIH with the preinitiation complex, affects the processivity of TFIIH kinase.Keywords
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