Mini-Mouse: Disruption of the Pygmy Locus in a Transgenic Insertional Mutant
- 23 February 1990
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 247 (4945), 967-969
- https://doi.org/10.1126/science.2305264
Abstract
A founder transgenic mouse harbored two different integration patterns of a transgene at the same locus, each of which gave rise to a similar autosomal recessive mutation. Mice of the mutant phenotype were of small stature but had normal levels of growth hormone. The disrupted locus was cloned, and a genetic and molecular analysis showed that the insertional mutants were allelic to a spontaneous mutant, pygmy. The mice should be a useful model for the growth hormone-resistant human dwarf syndromes and could lead to a greater understanding of the pathways involved in growth and development.Keywords
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