New method for assessing liver fibrosis based on acoustic radiation force impulse: a special reference to the difference between right and left liver
- 26 January 2011
- journal article
- Published by Springer Science and Business Media LLC in The Esophagus
- Vol. 46 (5), 705-711
- https://doi.org/10.1007/s00535-010-0365-7
Abstract
Virtual touch tissue quantification (VTTQ) based on acoustic radiation force impulse (ARFI) imaging has been developed as a noninvasive bedside method for the assessment of liver stiffness. In this study, we examined the diagnostic performance of ARFI imaging in 103 patients, focusing on the difference in VTTQ values between the right and left liver lobes. We evaluated VTTQ values of the right and left lobes in 79 patients with chronic liver disease who underwent histological examination of liver fibrosis and in 24 healthy volunteers. The diagnostic accuracy of VTTQ was compared with several serum markers, including hyaluronic acid, type 4 collagen, and aspartate transaminase to platelet ratio index. The VTTQ values (meters per second) in the right and left lobes were 1.61 ± 0.51 and 1.90 ± 0.68, respectively, and the difference was statistically significant (P < 0.0001). The VTTQ values in both liver lobes were correlated significantly with histological fibrosis grades (P < 0.001). The standard deviations of the VTTQ values in the right lobe were significantly lower than those in the left lobe (P < 0.001). The area under the receiver-operating characteristic curve for the diagnosis of fibrosis (F ≥ 3) using VTTQ values in both liver lobes was superior to serum markers, especially in the right lobe. VTTQ is an accurate and reliable tool for the assessment of liver fibrosis. VTTQ of the right lobe was more accurate for diagnosing liver fibrosis than in the left lobe.Keywords
This publication has 25 references indexed in Scilit:
- Evaluation of acoustic radiation force impulse elastography for fibrosis staging of chronic liver disease: a pilot studyLiver International, 2010
- Applicability and variability of liver stiffness measurements according to probe positionWorld Journal of Gastroenterology, 2009
- Assessment of Graft Fibrosis by Transient Elastography in Patients With Recurrent Hepatitis C After Living Donor Liver TransplantationTransplantation, 2008
- Imaging and Estimation of Tissue Elasticity by UltrasoundUltrasound Quarterly, 2007
- Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective studyGut, 2006
- Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis CHepatology, 2004
- Sampling variability of liver fibrosis in chronic hepatitis CHepatology, 2003
- National Institutes of Health Consensus Development Conference Statement: Management of hepatitis C: 2002-June 10-12, 2002Hepatology, 2002
- Identification of chronic hepatitis C patients without hepatic fibrosis by a simple predictive modelHepatology, 2002
- SAMPLING VARIABILITY AND ITS INFLUENCE ON THE DIAGNOSTIC YIELD OF PERCUTANEOUS NEEDLE BIOPSY OF THE LIVERThe Lancet, 1986