Proteolysis: from the lysosome to ubiquitin and the proteasome
- 1 January 2005
- journal article
- Published by Springer Science and Business Media LLC in Nature Reviews Molecular Cell Biology
- Vol. 6 (1), 79-87
- https://doi.org/10.1038/nrm1552
Abstract
How the genetic code is translated into proteins was a key focus of biological research before the 1980s, but how these proteins are degraded remained a neglected area. With the discovery of the lysosome, it was suggested that cellular proteins are degraded in this organelle. However, several independent lines of experimental evidence strongly indicated that non-lysosomal pathways have an important role in intracellular proteolysis, although their identity and mechanisms of action remained obscure. The discovery of the ubiquitin-proteasome system resolved this enigma.Keywords
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