Catheter-Related Deep Venous Thrombosis and Other Catheter Complications in Children With Cancer
- 1 October 2006
- journal article
- pediatric oncology
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 24 (28), 4575-4580
- https://doi.org/10.1200/jco.2005.05.5343
Abstract
Asymptomatic deep vein thrombosis (DVT) is a complication of central venous catheter (CVC) use in children with cancer, but its clinical significance is not well defined. Children with CVCs commonly experience two other CVC-related complications: occlusion and infection. The aim of this study was to determine the frequency of these two complications and their association with DVT. We conducted a retrospective cohort study of patients who were diagnosed with cancer. Data collected included number and type of catheter insertions, duration of use, reason for removal, associated catheter complications, and demographic information. Catheters were placed in 287 patients for a total of 128,403 days (mean, 290 ± 269 days/catheter). Of 21 patients (7%) diagnosed with CVC-related DVT, only five had specific signs or symptoms. Nineteen (90%) of these 21 children had prior history of catheter occlusion, and 10 of the 19 also experienced infection. Ten children (48%) were not identified as having DVT until they had had multiple catheters with recurrent complications. Odds of having DVT were higher in patients who had a single catheter complicated by repeated occlusions (odds ratio [OR], 3.7; P = .001) or infection (OR, 2.2; P = .016). Patients experiencing both infection and occlusion were at 6.4 times (P < .0001) higher risk of developing DVT. Children with CVC-related DVT frequently have recurrent catheter complications. Unrecognized thrombosis may therefore be clinically important. Prospective studies are needed to determine if identification and treatment of occult DVT will prevent additional CVC-related complications and prolong the duration of catheter use.Keywords
This publication has 19 references indexed in Scilit:
- Infectious Complications of Central Venous Catheters Increase the Risk of Catheter-Related Thrombosis in Hematology Patients: A Prospective StudyJournal of Clinical Oncology, 2005
- Prophylactic Urokinase in the Management of Long-Term Venous Access Devices in Children: A Children's Oncology Group StudyJournal of Clinical Oncology, 2004
- A prospective survey on incidence and outcome of Broviac/Hickman catheter-related complications in pediatric patients affected by hematological and oncological diseasesAnnals of Hematology, 2003
- Venous Thromboembolism Associated With Long-Term Use of Central Venous Catheters in Cancer PatientsJournal of Clinical Oncology, 2003
- Thrombotic complications of central venous catheters in childrenCurrent Opinion in Hematology, 2003
- Low-Dose Tissue Plasminogen Activator Thrombolysis in ChildrenJournal of Pediatric Hematology/Oncology, 2003
- Sleeve-Related Thrombosis: A New Form of Catheter-Related ThrombosisThrombosis Research, 2001
- Catheter-related thrombosis in children with cancerThe Journal of Pediatrics, 2001
- The Thrombophilic State Induced by Therapeutic Agents in the Cancer PatientSeminars in Thrombosis and Hemostasis, 1999
- Infection Rates of Broviac-Hickman Catheters and Implantable Venous DevicesArchives of Pediatrics & Adolescent Medicine, 1988