Correlates of Carotid Plaque Presence and Composition as Measured by MRI
- 1 July 2009
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation: Cardiovascular Imaging
- Vol. 2 (4), 314-322
- https://doi.org/10.1161/circimaging.108.823922
Abstract
Background— The composition of atherosclerotic plaque affects the likelihood of an atherothrombotic event, but prospective studies relating risk factors to carotid wall and plaque characteristics measured by MRI are lacking. We hypothesized that traditional risk factors are predictors of carotid wall and plaque characteristics measured 2 decades later. Methods and Results— A high-resolution contrast-enhanced MRI examination of the carotid artery was performed in 1769 participants. Measures of carotid wall volume and maximum thickness; lipid core presence, volume and maximum area; and fibrous cap thickness were performed centrally. The sample was, on average, 70 years of age, 57% female, 81% white, and 19% black. Greater age, total and low-density lipoprotein cholesterol, male sex, white race, diabetes, hypertension, and smoking as measured at baseline were all significant predictors of increased wall volume and maximum wall thickness 18 years later. An analysis of lipid core was restricted to the 1180 participants with maximum wall thickness ≥1.5 mm. Lipid core was observed in 569 individuals (weighted percentage, 42%). Baseline age and total and low-density lipoprotein cholesterol were predictors of presence of lipid core 18 years later; however, these relationships were attenuated after adjustment for wall thickness. Concurrently measured low-density lipoprotein cholesterol was associated with greater lipid core volume, independent of wall thickness. Concurrently measured glucose and body mass index were inversely associated fibrous cap thickness. Conclusions— Traditional atherosclerosis risk factors are related to increased wall volume and wall thickness 2 decades later, but they do not discriminate characteristics of plaque composition (core and cap) independent of wall size.Keywords
This publication has 26 references indexed in Scilit:
- Critical Cap Thickness and Rupture in Symptomatic Carotid PlaquesStroke, 2008
- The molecular mechanisms of the thrombotic complications of atherosclerosisJournal of Internal Medicine, 2008
- Abstracts From the 48th Annual Conference on Cardiovascular Disease Epidemiology and PreventionCirculation, 2008
- Risk Factor Associations With the Presence of a Lipid Core in Carotid Plaque of Asymptomatic Individuals Using High-Resolution MRIStroke, 2008
- Histopathology of Carotid Atherosclerotic DiseaseNeurosurgery, 2006
- Intra‐ and interreader reproducibility of magnetic resonance imaging for quantifying the lipid‐rich necrotic core is improved with gadolinium contrast enhancementJournal of Magnetic Resonance Imaging, 2006
- Histological Assessment of 526 Symptomatic Carotid Plaques in Relation to the Nature and Timing of Ischemic SymptomsCirculation, 2006
- Association Between Carotid Plaque Characteristics and Subsequent Ischemic Cerebrovascular EventsStroke, 2006
- Arterial Neovascularization and Inflammation in Vulnerable PatientsCirculation, 2004
- Distribution and correlates of sonographically detected carotid artery disease in the Cardiovascular Health Study. The CHS Collaborative Research Group.Stroke, 1992