The Progenitor Zone of the Ventral Medial Ganglionic Eminence Requires Nkx2-1 to Generate Most of the Globus Pallidus But Few Neocortical Interneurons
Open Access
- 24 February 2010
- journal article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 30 (8), 2812-2823
- https://doi.org/10.1523/jneurosci.4228-09.2010
Abstract
We show that most globus pallidus neurons, but very few neocortical interneurons, are generated from the ventral medial ganglionic eminence and dorsal preoptic area based on fate mapping using an Shh-Cre allele. The Shh-expressing subpallial lineage produces parvalbumin+GABAergic neurons, ChAT+cholinergic neurons, and oligodendrocytes. Loss of Nkx2-1 function from the Shh-expressing domain eliminated most globus pallidus neurons, whereas most cortical and striatal interneurons continued to be generated, except for striatal cholinergic neurons. Finally, our analysis provided evidence for a novel cellular component (Nkx2-1−;Npas1+) of the globus pallidus.Keywords
This publication has 37 references indexed in Scilit:
- Dlx1&2 and Mash1 Transcription Factors Control MGE and CGE Patterning and Differentiation through Parallel and Overlapping PathwaysCerebral Cortex, 2009
- Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdalaNature Neuroscience, 2009
- Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathwaysJournal of Comparative Neurology, 2008
- The Requirement of Nkx2-1 in the Temporal Specification of Cortical Interneuron SubtypesNeuron, 2008
- Postmitotic Nkx2-1 Controls the Migration of Telencephalic Interneurons by Direct Repression of Guidance ReceptorsNeuron, 2008
- Distinct molecular pathways for development of telencephalic interneuron subtypes revealed through analysis of Lhx6 mutantsJournal of Comparative Neurology, 2008
- A spatial bias for the origins of interneuron subgroups within the medial ganglionic eminenceDevelopmental Biology, 2008
- Dlx1 and Dlx2 Control Neuronal versus Oligodendroglial Cell Fate Acquisition in the Developing ForebrainNeuron, 2007
- Thyroid-Specific Enhancer-Binding Protein/NKX2.1 Is Required for the Maintenance of Ordered Architecture and Function of the Differentiated ThyroidMolecular Endocrinology, 2006
- The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neuronsEuropean Journal of Neuroscience, 2004