NUPACK: Analysis and design of nucleic acid systems
Top Cited Papers
Open Access
- 17 November 2010
- journal article
- research article
- Published by Wiley in Journal of Computational Chemistry
- Vol. 32 (1), 170-173
- https://doi.org/10.1002/jcc.21596
Abstract
The Nucleic Acid Package (NUPACK) is a growing software suite for the analysis and design of nucleic acid systems. The NUPACK web server (http://www.nupack.org) currently enables: Analysis: thermodynamic analysis of dilute solutions of interacting nucleic acid strands. Design: sequence design for complexes of nucleic acid strands intended to adopt a target secondary structure at equilibrium. Utilities: evaluation, display, and annotation of equilibrium properties of a complex of nucleic acid strands. NUPACK algorithms are formulated in terms of nucleic acid secondary structure. In most cases, pseudoknots are excluded from the structural ensemble. © 2010 Wiley Periodicals, Inc. J Comput Chem, 2010Keywords
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