Endocrine Complications after Hematopoietic Stem Cell Transplantation during Childhood and Adolescence
Open Access
- 1 January 2009
- journal article
- Published by Korean Academy of Medical Sciences in Journal of Korean Medical Science
- Vol. 24 (6), 1071-1077
- https://doi.org/10.3346/jkms.2009.24.6.1071
Abstract
Long-term survivors of hematopoietic stem cell transplantation (HSCT) during childhood and adolescence are at risk of developing endocrine complications. The purpose of this study was to evaluate the long-term endocrine complications and their associated risk factors among such patients. We reviewed the data from 111 patients (59 males and 52 females) who underwent HSCT at the mean age of 8.3±4.1 yr. Thirty patients (27.0%) had growth impairment, and seven (21.2%) out of 33 patients who attained final height reached final height below 2 standard deviation (SD). The final height SD score of the patients conditioned with total body irradiation (TBI) was significantly lower than that of the patients conditioned without TBI (-1.18±1.14 vs. -0.19±0.78, P=0.011). Thirteen patients (11.7%) developed hypothyroidism (11 subclinical, 2 central) 3.8±1.8 (range 1.6-6.2) yr after HSCT. Nineteen (65.5%) out of 29 females had evidence of gonadal dysfunction, and 18 (64.3%) out of 28 males had evidence of gonadal dysfunction. The risk for gonadal dysfunction was significantly higher in females conditioned with busulfan/cyclophosphamide (P=0.003). These results suggest that the majority of patients treated with HSCT during childhood and adolescence have one or more endocrine complications. Therefore, multiple endocrine functions should be monitored periodically after HSCT until they reach adult age.Keywords
This publication has 29 references indexed in Scilit:
- Comparison of long-term outcomes after allogeneic hematopoietic stem cell transplantation from matched sibling and unrelated donorsBone Marrow Transplantation, 2006
- Endocrine dysfunction and parameters of the metabolic syndrome after bone marrow transplantation during childhood and adolescenceBone Marrow Transplantation, 2006
- Diagnosis and Management of the Metabolic SyndromeCirculation, 2005
- Late thyroid toxicity in 153 long-term survivors of allogeneic bone marrow transplantation for acute lymphoblastic leukaemiaBone Marrow Transplantation, 2005
- Thyroid dysfunction after bone marrow transplantation for primary immunodeficiency without the use of total body irradiation in conditioningBone Marrow Transplantation, 2004
- Short‐ and long‐term follow‐up of thyroid dysfunction after allogeneic bone marrow transplantation without the use of preparative total body irradiationBritish Journal of Haematology, 1997
- Gonadal function after bone marrow transplantation for acute leukemia during childhoodThe Journal of Pediatrics, 1997
- Final height and hormonal function after bone marrow transplantation in childrenThe Journal of Pediatrics, 1996
- A Simple Method for Evaluation of Superoxide Radical Production in Neural Cells under Various Culture Conditions: Application to HypoxiaJournal of Cerebral Blood Flow & Metabolism, 1995
- Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty.Archives of Disease in Childhood, 1976