B7x: A widely expressed B7 family member that inhibits T cell activation
- 14 August 2003
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 100 (18), 10388-10392
- https://doi.org/10.1073/pnas.1434299100
Abstract
B7 family proteins provide costimulatory signals that regulate T cell responses. Here we report the third set of B7 family-related T cell inhibitory molecules with the identification of a homolog of the B7 family, B7x. It is expressed in immune cells, nonlymphoid tissues, and some tumor cell lines. B7x inhibits cell-cycle progression, proliferation, and cytokine production of both CD4+ and CD8+ T cells. B7x binds a receptor that is expressed on activated, but not resting T cells that is distinct from known CD28 family members. Its receptor may be a recently identified inhibitory molecule, B and T lymphocyte attenuator. These studies identify a costimulatory pathway that may have a unique function in downregulation of tissue-specific autoimmunity and antitumor responses.Keywords
This publication has 30 references indexed in Scilit:
- BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1Nature Immunology, 2003
- Expression and Regulation of the PD-L1 Immunoinhibitory Molecule on Microvascular Endothelial CellsMicrocirculation, 2002
- The B7 Family of Ligands and Its Receptors: New Pathways for Costimulation and Inhibition of Immune ResponsesAnnual Review of Immunology, 2002
- Expression and Regulation of the PD-L1 Immunoinhibitory Molecule on Microvascular Endothelial CellsMicrocirculation, 2002
- The B7–CD28 superfamilyNature Reviews Immunology, 2002
- The Cluster of BTN Genes in the Extended Major Histocompatibility ComplexGenomics, 2001
- Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte ActivationThe Journal of Experimental Medicine, 2000
- Enhancement of Antitumor Immunity by CTLA-4 BlockadeScience, 1996
- Extending the B7 (CD80) gene familyProtein Science, 1994
- Tumor Rejection After Direct Costimulation of CD8 + T Cells by B7-Transfected Melanoma CellsScience, 1993