Ethical Issues with Newborn Screening in the Genomics Era
- 22 September 2012
- journal article
- review article
- Published by Annual Reviews in Annual Review of Genomics and Human Genetics
- Vol. 13 (1), 381-393
- https://doi.org/10.1146/annurev-genom-090711-163741
Abstract
Continued technological advances have made the prospect of routine whole-genome sequencing (WGS) imminent. To date, much of the discussion about WGS has focused on its application and use in clinical medicine. Relatively little attention has been paid to the potential integration of WGS into newborn screening programs. Given the structure and scope of these programs, it is possible that the early applications of WGS will occur in state-run newborn screening programs. Assessment of the pressing ethical issues currently facing the newborn screening community will provide insight into the challenges that lie ahead in the genomics era.Keywords
This publication has 65 references indexed in Scilit:
- False-Positive Newborn Screening Result and Future Health Care Use in a State Medicaid CohortPEDIATRICS, 2011
- Storage and use of residual newborn screening blood spots: A public policy emergencyGenetics in Medicine, 2011
- Parental Attitudes toward Ethical and Social Issues Surrounding the Expansion of Newborn Screening Using New TechnologiesPublic Health Genomics, 2010
- Cystic Fibrosis Foundation Practice Guidelines for the Management of Infants with Cystic Fibrosis Transmembrane Conductance Regulator-Related Metabolic Syndrome during the First Two Years of Life and BeyondThe Journal of Pediatrics, 2009
- Maternal knowledge and attitudes about newborn screening for sickle cell disease and cystic fibrosisAmerican Journal of Medical Genetics Part A, 2009
- Impact of false-positive newborn metabolic screening results on early health care utilizationGenetics in Medicine, 2009
- Diagnostic dilemmas resulting from the immunoreactive trypsinogen/DNA cystic fibrosis newborn screening algorithmThe Journal of Pediatrics, 2005
- Talking with parents before newborn screeningThe Journal of Pediatrics, 2005
- A Clinical Trial of Alevaire in Pulmonary Distress of the Newborn InfantThe Journal of Pediatrics, 2005
- A Polymorphism in Plasma Platelet-activating Factor Acetylhydrolase is Involved in Resistance to Immunoglobulin Treatment in Kawasaki DiseaseThe Journal of Pediatrics, 2005