Energy on Demand
- 22 January 1999
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 283 (5401), 496-497
- https://doi.org/10.1126/science.283.5401.496
Abstract
New imaging techniques can see into the functioning brain, revealing the regions that are active during certain tasks and sensations. Magistretti et al ., in their Perspective, take this notion one step further and, by careful analysis of the biochemistry that gives rise to imaging signals, they deduce some of the cellular and molecular events that accompany neuronal activity in the working brain, ultimately laying the groundwork for determining the biochemistry that underlies human cognition.This publication has 7 references indexed in Scilit:
- An Increase in Lactate Output by Brain Tissue Serves to Meet the Energy Needs of Glutamate-Activated NeuronsJournal of Neuroscience, 1999
- Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activityProceedings of the National Academy of Sciences of the United States of America, 1998
- Synaptic Activation of Glutamate Transporters in Hippocampal AstrocytesNeuron, 1997
- Selective Distribution of Lactate Dehydrogenase Isoenzymes in Neurons and Astrocytes of Human BrainJournal of Cerebral Blood Flow & Metabolism, 1996
- Simultaneous Determination of the Rates of the TCA Cycle, Glucose Utilization, α-Ketoglutarate/Glutamate Exchange, and Glutamine Synthesis in Human Brain by NMRJournal of Cerebral Blood Flow & Metabolism, 1995
- Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.Proceedings of the National Academy of Sciences of the United States of America, 1994
- Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo.Proceedings of the National Academy of Sciences of the United States of America, 1993