Myocardial infarction causes inflammation and leukocyte recruitment at remote sites in the myocardium and in the renal glomerulus
Open Access
- 8 March 2013
- journal article
- research article
- Published by Springer Science and Business Media LLC in Inflammation Research
- Vol. 62 (5), 515-525
- https://doi.org/10.1007/s00011-013-0605-4
Abstract
Acute myocardial infarction (AMI) results in the recruitment of leukocytes to injured myocardium. Additionally, myocardium remote to the infarct zone also becomes inflamed and is associated with adverse left ventricular remodelling. Renal ischaemic syndromes have been associated with remote organ inflammation and impaired function. Here, we tested the hypothesis that AMI results in remote organ (renal) inflammation. Mice were subjected to either AMI, sham procedure or no procedure and the inflammatory response in peripheral blood, injured and remote myocardium, and kidneys was studied at 24 h. AMI resulted in increased circulating neutrophils (P < 0.001) and monocytes (P < 0.001). mRNA for inflammatory mediators significantly increased in infarcted myocardium and in remote myocardium. VCAM-1 mRNA was increased in both infarcted and remote myocardium. VCAM-1 protein was also increased in the kidneys of AMI mice (P < 0.05) and immunofluorescence revealed localisation of VCAM-1 to glomeruli, associated with leukocyte infiltration and increased local inflammatory mRNA expression. We conclude that in addition to local inflammation, AMI results in remote organ inflammation evidenced by (1) increased expression of mRNA for inflammatory cytokines, (2) marked upregulation of VCAM-1 in renal glomeruli, and (3) the recruitment and infiltration of leukocytes in the kidney.Keywords
This publication has 55 references indexed in Scilit:
- Interleukin‐1β modulation using a genetically engineered antibody prevents adverse cardiac remodelling following acute myocardial infarction in the mouseEuropean Journal of Heart Failure, 2010
- Long-term Prognosis of Acute Kidney Injury After Acute Myocardial InfarctionJAMA Internal Medicine, 2008
- Long-term Risk of Mortality and End-Stage Renal Disease Among the Elderly After Small Increases in Serum Creatinine Level During Hospitalization for Acute Myocardial InfarctionArchives of Internal Medicine, 2008
- The Local and Systemic Inflammatory Transcriptome after Acute Kidney InjuryJournal of the American Society of Nephrology, 2008
- The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functionsThe Journal of Experimental Medicine, 2007
- Acute Renal Failure after Bilateral Nephrectomy Is Associated with Cytokine-Mediated Pulmonary InjuryJournal of the American Society of Nephrology, 2007
- Acute Kidney Injury, Mortality, Length of Stay, and Costs in Hospitalized PatientsJournal of the American Society of Nephrology, 2005
- Systemic Inflammatory Response Syndrome After Acute Myocardial Infarction Complicated by Cardiogenic ShockArchives of Internal Medicine, 2005
- Transgenic Sickle Mice Are Markedly Sensitive to Renal Ischemia-Reperfusion InjuryThe American Journal of Pathology, 2005
- Systemic Inflammation and Reperfusion Injury in Patients With Acute Myocardial InfarctionMediators of Inflammation, 2005