FUSED CYANOPYRIMIDINES: PART-I SYNTHESIS AND REACTIONS OF FUSED CYANOPYRIMIDINE DERIVATIVES AND THEIR EFFECT ON CELLOBIASE ACTIVITY

Abstract

Some new fused heterotricyclic systems containing the cyanopyrimidine moiety have been synthesized from the interaction between 2-mercapto-4-arylidene-5-cyanopyrimidin-6(1H)one (1) with bi-functional halogen and nitrogen compounds. Structures of the new products have been established by elemental analyses and spectral data (UV, IR, ¹H NMR and mass). Effect of the newly synthesized compounds on the activity of the cellobiase produced by Aspergillus nidulans was studied.