Effect of Ketone Bodies on Hyperglycemia and Lactic Acidemia in Hemorrhagic Stress
- 1 September 1994
- journal article
- Published by Wiley in Journal of Parenteral and Enteral Nutrition
- Vol. 18 (5), 442-446
- https://doi.org/10.1177/0148607194018005442
Abstract
Background: To investigate the effect of hyperketonemia on altered glucose metabolism under stress conditions, we infused sodium D‐3‐hydroxybutyrate (3‐OHB) into rats in hemorrhagic hypotension and evaluated the plasma concentration of substrates related to glucose metabolism. Methods: Three groups of anesthetized rats (weight, 280 g to 320 g) were bled acutely, and their mean arterial pressures were maintained at 40 mm Hg. From 1 hour before hemorrhage to the end of the experiment, rats in the first group (n = 10) were infused with 3‐OHB at a rate of 30 μmol/kg·min (3‐OHB group), those in the second group (n = 10) received glucose and sodium bicarbonate (glucose group), and the remaining 10 rats received only sodium bicarbonate and no energy substrates (control group). Sodium bicarbonate was used to control the alkalizing effect of 3‐OHB. Results: Hyperketonemia(1158± 30 μmol/L ‐ 1618 ± 154 μmol/L) occurred only in the 3‐OHB group. Hyperglycemia and lactic acidemia during hemorrhagic shock were suppressed significantly compared with the control group. Plasma concentration of alanine was also lower compared with the control group. In the glucose group, although plasma lactate concentration was lower, plasma glucose concentration was not suppressed, and plasma alanine concentration was higher in comparison with the control group during hemorrhagic shock. There was no significant difference in plasma insulin concentration among the three groups. Conclusions: These results suggest that administered 3‐OHB may suppress glycolysis during hemorrhagic shock. (Journal of Parenteral and Enteral Nutrition 18:442–446, 1994)Keywords
This publication has 14 references indexed in Scilit:
- Effect of Sodium D-3-Hydroxybutyrate on Amino Acidemia in Hemorrhagic HypotensionEuropean Surgical Research, 1991
- Sensitive and simplified method for the differential determination of serum levels of ketone bodiesClinica Chimica Acta; International Journal of Clinical Chemistry, 1983
- New detection and separation method for amino acids by high-performance liquid chromatographyJournal of Chromatography A, 1981
- Functional Stoichiometric Coupling and Metabolic PricesPublished by Elsevier BV ,1977
- Blood Ketone Body Disappearance Rate in Diabetics and Normals after Rapid Infusion of DL‐3‐hydroxybutyrateActa Medica Scandinavica, 1976
- Effect of ketone infusions on amino acid and nitrogen metabolism in man.JCI Insight, 1975
- An effect of ketones on the concentrations of glucose and of free fatty acids in man independent of the release of insulinThe Journal of Pediatrics, 1974
- Experimental and Clinical Studies on Lactate and Pyruvate as Indicators of the Severity of Acute Circulatory Failure (Shock)Circulation, 1970
- The regulation of the release of ketone bodies by the liverAdvances in Enzyme Regulation, 1966
- Regulation of glucose uptake by muscle. 7. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes, starvation, hypophysectomy and adrenalectomy, on the concentrations of hexose phosphates, nucleotides and inorganic phosphate in perfused rat heartBiochemical Journal, 1964