COVID‐19 vaccine‐associated immune thrombosis and thrombocytopenia (VITT): Diagnostic and therapeutic recommendations for a new syndrome
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Open Access
- 13 May 2021
- journal article
- review article
- Published by Wiley in European Journal of Haematology
- Vol. 107 (2), 173-180
- https://doi.org/10.1111/ejh.13665
Abstract
Very rare cases of thrombosis associated with thrombocytopenia have occurred following the vaccination with AstraZeneca COVID‐19 vaccine. The aim of this concise review is to summarize the current knowledge on the epidemiologic and pathogenic mechanisms of this syndrome named vaccine‐associate immune thrombosis and thrombocytopenia (VITT). A practical patient management section will also be dealt with using information available from national and international scientific societies as well as expert panels. A literature search on the VITT syndrome was carried out in PubMed using appropriate MeSH headings. Overall, 40 VITT cases have been reported. Continuous pharmacovigilance monitoring is needed to collect more data on the real incidence and the pathogenesis of VITT syndrome. Such information will also help us to optimize the management this rare but often clinically severe thrombotic condition associated with COVID‐19 vaccination.Keywords
This publication has 32 references indexed in Scilit:
- Risk factors for heparin-induced thrombocytopenia: Focus on Fcγ receptorsThrombosis and Haemostasis, 2016
- Heparin-Induced ThrombocytopeniaThe New England Journal of Medicine, 2015
- Platelet factor 4 binding to lipid A of Gram-negative bacteria exposes PF4/heparin-like epitopesBlood, 2012
- Platelet factor 4 binds to bacteria, inducing antibodies cross-reacting with the major antigen in heparin-induced thrombocytopeniaBlood, 2011
- Fatal heparin‐induced thrombocytopenia (HIT) during warfarin thromboprophylaxis following orthopedic surgery: another example of ‘spontaneous’ HIT?Journal of Thrombosis and Haemostasis, 2008
- A Spontaneous Prothrombotic Disorder Resembling Heparin-induced ThrombocytopeniaThe American Journal of Medicine, 2008
- Adenovirus-Platelet Interaction in Blood Causes Virus Sequestration to the Reticuloendothelial System of the LiverJournal of Virology, 2007
- Treatment with the novel anti-angiogenic agent PI-88 is associated with immune-mediated thrombocytopeniaAnnals of Oncology, 2002
- Pentosan‐induced thrombocytopenia: support for an immune complex mechanismBritish Journal of Haematology, 1994
- Pentosan polysulfate‐induced thrombocytopenia and thrombosisAmerican Journal of Hematology, 1994