HIV-specific CD8+ T cells and HIV eradication
Open Access
- 5 January 2016
- journal article
- review article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 126 (2), 455-463
- https://doi.org/10.1172/jci80566
Abstract
After the success of combination antiretroviral therapy (cART) to treat HIV infection, the next great frontier is to cure infected persons, a formidable challenge. HIV persists in a quiescent state in resting CD4+ T cells, where the replicative enzymes targeted by cART are not active. Although low levels of HIV transcripts are detectable in these resting cells, little to no viral protein is produced, rendering this reservoir difficult to detect by the host CD8+ T cell response. However, recent advances suggest that this state of latency might be pharmacologically reversed, resulting in viral protein expression without the adverse effects of massive cellular activation. Emerging data suggest that with this approach, infected cells will not die of viral cytopathic effects, but might be eliminated if HIV-specific CD8+ T cells can be effectively harnessed. Here, we address the antiviral properties of HIV-specific CD8+ T cells and how these cells might be harnessed to greater effect toward achieving viral eradication or a functional cure.Keywords
This publication has 157 references indexed in Scilit:
- Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus ReactivationImmunity, 2012
- Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunityNature, 2012
- Profound early control of highly pathogenic SIV by an effector memory T-cell vaccineNature, 2011
- Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell–mediated immunityNature Medicine, 2010
- Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, diminishes lymphoproliferation in the Fas -deficient MRL/lpr−/− murine model of autoimmune lymphoproliferative syndrome (ALPS)Experimental Hematology, 2009
- Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virusNature Immunology, 2009
- Enhancing SIV-specific immunity in vivo by PD-1 blockadeNature, 2008
- Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infectionNature Immunology, 2008
- Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptorNature Medicine, 2008
- Direct observation of ligand recognition by T cellsNature, 2002