Association between WHO cut-offs for childhood overweight and obesity and cardiometabolic risk
- 31 October 2012
- journal article
- research article
- Published by Cambridge University Press (CUP) in Public Health Nutrition
- Vol. 16 (4), 625-630
- https://doi.org/10.1017/s1368980012004776
Abstract
Objective: To examine the association between cardiovascular risk and childhood overweight and obesity using the BMI cut-offs recommended by the WHO.Design: Children were classified as normal weight, overweight and obese according to the WHO BMI-for-age reference. Blood pressure, lipids, glucose, insulin, homeostasis model assessment–insulin resistance (HOMA-IR) and uric acid levels were compared across BMI groups. ANOVA and tests of linearity were used to assess overall mean differences across groups. Crude and adjusted odds ratios were calculated for adverse plasma levels of biochemical variables.Setting: Paediatric care centres.Subjects: Children (n149) aged 8–18 years.Results: About 37 %, 22 % and 41 % of children were classified respectively as normal weight, overweight and obese. There were significant linear mean differences between BMI groups in systolic blood pressure, HDL-cholesterol, TAG, insulin, HOMA-IR and uric acid. Obese children were 10·6 times more likely than normal-weight children to have hypertension; OR for other associations were 60·2 (high insulin), 39·5 (HOMA-IR), 27·9 (TAG), 16·0 (HDL-cholesterol), 4·3 (LDL-cholesterol) and 3·6 (uric acid). Overweight children were more likely than normal-weight children to have hypertension (OR = 3·5), high insulin (OR = 28·2), high HOMA-IR (OR = 23·3) and high TAG (OR = 16·1). Nearly 92 % and 57 % of the obese and overweight children, respectively, had one or more risk factor.Conclusions: Obesity and overweight defined using the WHO BMI-for-age cut-offs identified children with higher metabolic and vascular risk. These results emphasize the importance of prevention of overweight and obesity in childhood to reduce cardiovascular risk.Keywords
This publication has 19 references indexed in Scilit:
- Extended international (IOTF) body mass index cut‐offs for thinness, overweight and obesityPediatric Obesity, 2012
- Association between different growth curve definitions of overweight and obesity and cardiometabolic risk in childrenCMAJ : Canadian Medical Association Journal, 2012
- Non-alcoholic fatty liver disease in childrenBMJ, 2011
- Defining obesity risk status in the general childhood population: Which cut-offs should we use?Pediatric Obesity, 2010
- Global prevalence and trends of overweight and obesity among preschool childrenThe American Journal of Clinical Nutrition, 2010
- Obesity indicators and cardiometabolic status in 4-y-old childrenThe American Journal of Clinical Nutrition, 2010
- Prevalence of metabolic syndrome in European obese childrenPediatric Obesity, 2008
- Development of a WHO growth reference for school-aged children and adolescentsPublished by WHO Press ,2007
- America’s ChildrenCirculation, 2005
- The Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and AdolescentsPediatrics, 2004