Effects of Finite Size on Selection Advance in Simulated Genetic Populations

Abstract

The design and analysis of an investigation of selection in simulated genetic populations is discussed. The long-range objectives and specification of parameters and models are outlined, and certain mechanics of simulation of genetic systems are included, some of which may be of general application to Monte Carlo investigations. The results from selection in small simulated populations under 9 different models of gene action are discussed with respect to the effects of population size on inbreeding depression and the random drift of gene frequency.