Advances in male hormone substitution therapy
- 8 August 2005
- journal article
- review article
- Published by Informa UK Limited in Expert Opinion on Pharmacotherapy
- Vol. 6 (9), 1493-1506
- https://doi.org/10.1517/14656566.6.9.1493
Abstract
Increased awareness of the clinical diagnosis of male hypogonadism has resulted in the wider use of androgen substitution therapy. Clinical signs and symptoms together with a low serum testosterone level confirm the diagnosis of male hypogonadism. Androgen replacement results in improved sexual function, mood, muscle mass and bone density in most hypogonadal men. Such benefits must be assessed against potential risks. In older men, the potential risks of androgen treatment of hypogonadism are not known. Many delivery systems for androgen substitution are now available; the preparation chosen depends on the choice of the patient and his physician. Selective androgen receptor modulators offer tissue selective biological effects and the possibility of attaining maximum efficacy and minimum adverse effects.Keywords
This publication has 115 references indexed in Scilit:
- Can results of the Aging Males' Symptoms (AMS) scale predict those of screening scales for androgen deficiency?The Aging Male, 2004
- Testosterone treatment for men with chronic heart failureHeart, 2004
- Serum adiponectin levels in hypogonadal males: influence of testosterone replacement therapyClinical Endocrinology, 2004
- Testosterone Gel Supplementation for Men With Refractory Depression: A Randomized, Placebo-Controlled TrialAmerican Journal of Psychiatry, 2003
- Effect of Testosterone and Estradiol in a Man with Aromatase DeficiencyNew England Journal of Medicine, 1997
- Testosterone influences spatial cognition in older men.Behavioral Neuroscience, 1994
- Transdermal Dihydrotestosterone Treatment of 'Andropause'Annals of Medicine, 1993
- TRANSDERMAL TESTOSTERONE SUBSTITUTION THERAPY FOR MALE HYPOGONADISMThe Lancet, 1986
- Obstructive Sleep Apnea Syndrome Induced by Testosterone AdministrationNew England Journal of Medicine, 1983
- Calculation of free and bound fractions of testosterone and estradiol-17β to human plasma proteins at body temperatureJournal of Steroid Biochemistry, 1982