Emergence of Colistin Resistance Gene mcr-1 in Cronobacter sakazakii Producing NDM-9 and in Escherichia coli from the Same Animal

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Abstract
We report the presence of mcr-1 in Escherichia coli and carbapenem-resistant Cronobacter sakazakii from the same diseased chicken. The mcr-1 gene linked with IS Apl1 was located on two different IncI2 plasmids, including one multidrug plasmid in E. coli , whereas fosA3-bla NDM-9 was on an IncB/O plasmid in C. sakazakii . The development of the fosA3-bla NDM-9 resistance region was mediated by IS 26 . The colocation of mcr-1 or bla NDM-9 with other resistance genes will accelerate the dissemination of the two genes.
Funding Information
  • The National Natural Science Foundation of China (31502122)
  • the Natural Science Foundation of Shandong Province of China (BS2015NY005)
  • the Advanced Talents Foundation of Qingdao Agricultural University (663/1115014)
  • The Scientific and Technological Projects of Qingdao (16-5-1-49-jch)