Cerebrospinal fluid confirmed COVID-19-associated encephalitis treated successfully
Open Access
- 1 September 2020
- journal article
- research article
- Published by BMJ in BMJ Case Reports
- Vol. 13 (9), e237378
- https://doi.org/10.1136/bcr-2020-237378
Abstract
The COVID-19 pandemic that attracted global attention in December 2019 is well known for its clinical picture that is consistent with respiratory symptoms. Currently, the available medical literature describing the neurological complications of COVID-19 is gradually emerging. We hereby describe a case of a 31-year-old COVID-19-positive patient who was admitted on emergency basis. His clinical presentation was primarily neurological, rather than the COVID-19's classical respiratory manifestations. He presented with acute behavioural changes, severe confusion and drowsiness. The cerebrospinal fluid analysis was consistent with COVID-19 encephalitis, as well as the brain imaging. This experience confirms that neurological manifestations might be expected in COVID-19 infections, despite the absence of significant respiratory symptoms. Whenever certain red flags are raised, physicians who are involved in the management of COVID-19 should promptly consider the possibility of encephalitis. Early recognition of COVID-19 encephalitis and timely management may lead to a better outcome.This publication has 17 references indexed in Scilit:
- 1823. Incidence of Meningoencephalitis in the Absence of CSF PleocytosisOpen Forum Infectious Diseases, 2019
- Central nervous system infections in the absence of cerebrospinal fluid pleocytosisInternational Journal of Infectious Diseases, 2017
- Analysis of clinical outcomes in pediatric bacterial meningitis focusing on patients without cerebrospinal fluid pleocytosisJournal of Microbiology, Immunology and Infection, 2016
- Normocellular CSF in herpes simplex encephalitisBMC Research Notes, 2016
- Work ability and associated factors of Brazilian technical-administrative workers in educationBMC Research Notes, 2016
- Cerebrospinal fluid white cell count: discriminatory or otherwise for enteroviral meningitis in infants and young children?Journal of NeuroVirology, 2015
- ACE2-Ang-(1-7)-Mas Axis in Brain: A Potential Target for Prevention and Treatment of Ischemic StrokeCurrent Neuropharmacology, 2013
- Epidemiology and Clinical Presentations of the Four Human Coronaviruses 229E, HKU1, NL63, and OC43 Detected over 3 Years Using a Novel Multiplex Real-Time PCR MethodJournal of Clinical Microbiology, 2010
- Neurological manifestations in severe acute respiratory syndrome.2005
- Large artery ischaemic stroke in severe acute respiratory syndrome (SARS)Zeitschrift für Neurologie, 2004