Clinical Efficacy of Halophilic Lactic Acid Bacterium Tetragenococcus halophilus Th221 from Soy Sauce Moromi for Perennial Allergic Rhinitis
Open Access
- 1 January 2009
- journal article
- research article
- Published by Japanese Society of Allergology in Allergology International
- Vol. 58 (2), 179-185
- https://doi.org/10.2332/allergolint.o-08-548
Abstract
Recently, some common foods in daily life, especially lactic acid bacteria, have been found to have anti-allergic effects. We previously isolated a halophilic lactic acid bacterium, Tetragenococcus halophilus Th221, from soy sauce moromi, a mixture of koji and salt solution, and showed that it possesses an immunomodulatory activity that promotes T helper type 1 immunity.To evaluate the anti-allergic effects of Th221, we performed a randomized, double-blind, placebo-controlled study in 45 subjects with perennial allergic rhinitis (PAR) treated by oral administration of Th221 (high dose, 60 mg/day, 15 subjects; low dose, 20.4 mg/day, 15 subjects) or a placebo (15 subjects) for 8 weeks.There were no significant differences among the groups that ingested Th221 and the placebo group regarding the disease severities, total nasal symptom scores and total nasal sign scores examined by physicians. However, the disease severity examined by physicians significantly improved in the high-dose group at the end of the trial compared with the beginning (p < 0.05). The total score for nasal symptoms of subjects who received a high dose of Th221 also showed a significant improvement at the end of the trial compared with the beginning (p < 0.01). According to the subjects' diaries, significant improvements in sneezing and rhinorrhea were observed during some periods in the high-dose group. The change in serum total immunoglobulin E improved significantly at the end of the trial compared with the beginning in this group (p < 0.05). The safety of Th221 treatment was confirmed by laboratory tests and inspection of the general condition of each subject.Th221 can be expected to safely improve the symptoms of PAR.Keywords
This publication has 21 references indexed in Scilit:
- Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*Allergy, 2008
- Immunomodulatory effect of halophilic lactic acid bacterium Tetragenococcus halophilus Th221 from soy sauce moromi grown in high-salt mediumInternational Journal of Food Microbiology, 2008
- An Evaluation of the Clinical Efficacy of Tomato Extract for Perennial Allergic RhinitisAllergology International, 2007
- Clinical Efficacy of Probiotic Bifidobacterium longum for the Treatment of Symptoms of Japanese Cedar Pollen Allergy in Subjects Evaluated in an Environmental Exposure UnitAllergology International, 2007
- Clinical Effects of Lactobacillus acidophilus Strain L-92 on Perennial Allergic Rhinitis: A Double-Blind, Placebo-Controlled StudyJournal of Dairy Science, 2005
- The Anti-Allergic Effects of Lactic Acid Bacteria Are Strain Dependent and Mediated by Effects on both Th1/Th2 Cytokine Expression and BalanceInternational Archives of Allergy and Immunology, 2004
- Anti-allergy properties of fermented foods: an important immunoregulatory mechanism of lactic acid bacteria?International Immunopharmacology, 2001
- Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trialThe Lancet, 2001
- The Effect of Oral Feeding of Lactobacillus casei Strain Shirota on Immunoglobulin E Production in MiceJournal of Dairy Science, 1998
- Clinical and histopathologic studies of the nose and sinuses in allergyJournal of Allergy, 1929