Association between tobacco smoke exposure and levels of C-reactive protein in the Oslo II Study
- 5 May 2007
- journal article
- Published by Springer Science and Business Media LLC in European Journal of Epidemiology
- Vol. 22 (5), 311-317
- https://doi.org/10.1007/s10654-007-9121-6
Abstract
It is well known that tobacco smoke exposure is related to the risk of developing cardiovascular diseases and events. One mechanism could be that tobacco smoke acts on the cardiovascular system by altering the autonomic function and/or inducing inflammatory responses. We used data from 3 744 men aged 67–77 years from the city of Oslo that participated in the health screening for the Oslo II Health Study in 2000, to explore associations between C-reactive protein and environmental exposures including exposure to tobacco smoke products. Levels of C-reactive protein were higher in current smokers (2.05 mg/l, IQR, 1.11–4.17 mg/l), compared to former-smokers (1.58 mg/l, IQR, 0.83–3.03 mg/l) and non-smokers (1.26 mg/l, IQR, 0.65–2.40 mg/l). The risk of elevated C-reactive protein increased with both numbers of current cigarettes smoked per day and numbers of pack-years of smoking, when other factors were adjusted for (P < 0.001). We found a positive dose–response relationship between amount of current cigarette smoking and elevated C-reactive protein levels. These findings support the idea that the induction or exacerbation of inflammation could be a mechanism by which smoking promotes atherosclerotic cardiovascular diseases.Keywords
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