Antibacterial Activity of Some 3-(Arylideneamino)-2-phenylquinazoline-4(3H)-ones: Synthesis and Preliminary QSAR Studies
Open Access
- 30 October 2007
- Vol. 12 (10), 2413-2426
- https://doi.org/10.3390/12102413
Abstract
Synthesis of ten 3-(arylideneamino)-2-phenylquinazoline-4(3H)-ones is reported. All the compounds contained a common phenyl group at the 2-position, while the substituents on the arylideneamino group were varied. The compounds were investigated for their antimicrobial activity against both Gram-positive (Staphylococcus aureus 6571 and Bacillus subtilis) and Gram-negative bacteria (Escherichia coli K12 and Shigella dysenteriae 6) using a turbidometric assay method. It was found that the incorporation of the 3-arylideneamino substituent enhanced the anti-bacterial activity of the quinazolone system. The preliminary QSAR studies were done using some computer derived property descriptors, calculated values of partition coefficients as well as usual Hammett’s sigma constants and the substituent’s molar refractivity.This publication has 13 references indexed in Scilit:
- ChemInform Abstract: Synthesis and Biological Activity of Some 2-Substituted Quinazolin-4-ones.ChemInform, 2010
- Synthesis and CNS depressant activity of some novel 3-[5-substituted 1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3H)-onesEuropean Journal of Medicinal Chemistry, 2008
- A Polymer-Assisted Solution-Phase Strategy for the Synthesis of Fused [2,1-b]Quinazolinones and the Preparation of Optically Active VasicinoneSynlett, 2006
- Incidence of class 1 integrons in multiple antibiotic-resistant Gram-negative copiotrophic bacteria from the River Torsa in IndiaResearch in Microbiology, 2006
- AntiHIV, antibacterial and antifungal activities of some novel 1,4-disubstituted-1,2,4-triazolo[4,3-a] quinazolin-5(4h)-onesIndian Journal of Pharmaceutical Sciences, 2006
- Inhibitory study of some novel Schiff base derivatives on Staphylococcus aureus by microcalorimetryThermochimica Acta, 2006
- Synthesis, Analgesic, Anti-inflammatory and Antibacterial Activities of Some Novel 2-Phenyl-3-substituted Quinazolin-4(3H) Ones.Biological & Pharmaceutical Bulletin, 2002
- Antibacterial Schiff Bases of Oxalyl-hydrazine/diamide Incorporating Pyrrolyl and Salicylyl Moieties and of Their Zinc(II) ComplexesJournal of Enzyme Inhibition and Medicinal Chemistry, 2002
- Synthesis and biological evaluation of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerizationJournal of Medicinal Chemistry, 1990
- Substituted 2,3-Dihydro-4(1H)-quinazolinones. A New Class of Inhibitors of Cell MultiplicationJournal of Medicinal Chemistry, 1967