Insulin and the vasculature
- 1 March 2000
- journal article
- Published by Springer Science and Business Media LLC in Current Hypertension Reports
- Vol. 2 (2), 148-153
- https://doi.org/10.1007/s11906-000-0074-3
Abstract
Under physiologic conditions, insulin plays a vasculoprotective role by acting as a vasodilator through the stimulation of nitric oxide synthesis and release from the endothelium. In addition, insulin may decrease the contractile response of vascular smooth muscle cells (VSMC) to vasoactive agents by decreasing the intracellular calcium concentration [Ca2+]i. However, in the insulin resistance syndrome, the vasodilator effect of insulin may be blunted, an abnormality that may be related to endothelial dysfunction. Insulin resistance correlates with carotid wall thickness and stiffness, but the relationship is modified by sex and ethnic factors. Insulin can act as growth factor stimulating VSMC growth in culture. Insulin-sensitizing agents are efficacious in improving the vascular pathology associated with insulin resistance.Keywords
This publication has 43 references indexed in Scilit:
- Vascular reactivityThe American Journal of Cardiology, 1999
- TNF-α–Induced Migration of Vascular Smooth Muscle Cells Is MAPK DependentHypertension, 1999
- Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)The Lancet, 1998
- Stiffness Indexes β of the Common Carotid and Femoral Arteries Are Associated With Insulin Resistance in NIDDMDiabetes Care, 1998
- Nitric oxide release accounts for insulin's vascular effects in humans.JCI Insight, 1994
- Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.JCI Insight, 1994
- Insulin attenuates agonist-mediated calcium mobilization in cultured rat vascular smooth muscle cells.JCI Insight, 1993
- Skeletal muscle blood flow. A possible link between insulin resistance and blood pressure.Hypertension, 1993
- Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.JCI Insight, 1989
- The Pathogenesis of Atherosclerosis — An UpdateNew England Journal of Medicine, 1986