ASSESSMENT OF RADIOCONTRAST MEDIA INDUCED RENAL VASOCONSTRICTION BY COLOR CODED DUPLEXSONOGRAPHY
- 1 January 2001
- journal article
- Published by Taylor & Francis Ltd in Renal Failure
- Vol. 23 (1), 77-83
- https://doi.org/10.1081/jdi-100001286
Abstract
Introduction: Changes in renal hemodynamics are suspected to be one of the major pathogenetic correlates in radiocontrast media-induced nephrotoxicity. We investigated whether color-coded duplex sonography is an appropriate method to document changes in intrarenal vascular resistance, after intravenous injection of the low-osmolar contrast material Iopamidol. Methods: Intrarenal arterial doppler wave forms were analyzed every minute after intravenous injection of 100 mL Iopamidol in 10 patients during a voiding cystourogram-procedure. The Resistive Index (RI) of each flow curve, reflecting intrarenal flow resistance, was calculated and compared to the mean of four RI measurements taken before contrast media application. Results: One minute after injection of Iopamidol the RI remained unchanged compared to the baseline standard of 0.70. In measurements obtained 2, 3, 4, and 5 minutes after Iopamidol injection a statistically significant rise was seen: (minute 2: 0.74, p < 0.001/minute 3: 0.75, p = 0.001/minute 4: 0.72, p = 0.018/minute 5: 0.74, p = 0.031). During the further course, the resistive indices decreased progressively and showed no significant difference in comparison with the baseline standard value. Conclusion: Color coded duplex sonography is a simple method to detect changes in renal flow resistance after application of radiocontrast media. Based on our results, we believe that the analysis of intrarenal arterial doppler flow profiles constitutes an ideal method to investigate pathophysiologic mechanisms of radiocontrast media-induced nephrotoxicity, as well as pharmacological concepts in nephroprotectivity.Keywords
This publication has 20 references indexed in Scilit:
- Prevention of radiocontrast-media-induced nephropathy in patients with pre-existing renal insufficiency by hydration in combination with the adenosine antagonist theophylline.Nephrology Dialysis Transplantation, 1999
- Renal Effects of Low and Isoosmolar Contrast Media on Renal Hemodynamic in a Normal and Ischemic Dog KidneyInvestigative Radiology, 1999
- Prevention of Contrast Medium-Induced Renal Vasospasm by Phosphodiesterase InhibitionInvestigative Radiology, 1998
- Comparison of Iodinated Contrast Media-Induced Renal Vasoconstriction in Human, Rabbit, Dog, and Pig ArteriesInvestigative Radiology, 1997
- Vasoconstriction of Isolated Arteries Induced by Angiographic Contrast MediaActa Radiologica, 1995
- Metaanalysis of the relative nephrotoxicity of high- and low-osmolality iodinated contrast media.Radiology, 1993
- Dopamine and Renall Blood Flow in Radiocontrast-Induced Nephropathy in HumansRenal Failure, 1993
- Effects on Renal Hemodynamics and Tubular Function of the Contrast Medium Iohexol in Renal PatientsRenal Failure, 1990
- Renal Hemodynamics during Selective Renal AngiographyInvestigative Radiology, 1968
- Effect of Aortography on Renal Hemodynamics in Normal ManInvestigative Radiology, 1968