Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance
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Open Access
- 1 January 2008
- journal article
- research article
- Published by Elsevier BV in The American Journal of Clinical Nutrition
- Vol. 87 (1), 142-149
- https://doi.org/10.1093/ajcn/87.1.142
Abstract
Background: Exercise practitioners often take vitamin C supplements because intense muscular contractile activity can result in oxidative stress, as indicated by altered muscle and blood glutathione concentrations and increases in protein, DNA, and lipid peroxidation. There is, however, considerable debate regarding the beneficial health effects of vitamin C supplementation. Objective: This study was designed to study the effect of vitamin C on training efficiency in rats and in humans. Design: The human study was double-blind and randomized. Fourteen men (27–36 y old) were trained for 8 wk. Five of the men were supplemented daily with an oral dose of 1 g vitamin C. In the animal study, 24 male Wistar rats were exercised under 2 different protocols for 3 and 6 wk. Twelve of the rats were treated with a daily dose of vitamin C (0.24 mg/cm2 body surface area). Results: The administration of vitamin C significantly (P = 0.014) hampered endurance capacity. The adverse effects of vitamin C may result from its capacity to reduce the exercise-induced expression of key transcription factors involved in mitochondrial biogenesis. These factors are peroxisome proliferator–activated receptor co-activator 1, nuclear respiratory factor 1, and mitochondrial transcription factor A. Vitamin C also prevented the exercise-induced expression of cytochrome C (a marker of mitochondrial content) and of the antioxidant enzymes superoxide dismutase and glutathione peroxidase. Conclusion: Vitamin C supplementation decreases training efficiency because it prevents some cellular adaptations to exercise.Keywords
This publication has 33 references indexed in Scilit:
- Health benefits of physical activity: the evidenceCMAJ : Canadian Medical Association Journal, 2006
- Decreasing xanthine oxidase‐mediated oxidative stress prevents useful cellular adaptations to exercise in ratsThe Journal of Physiology, 2005
- Vitamins E and C are safe across a broad range of intakes1,2The American Journal of Clinical Nutrition, 2005
- Beneficial effects of moderate exercise on mice aging: survival, behavior, oxidative stress, and mitochondrial electron transferAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2004
- Effect of Vitamin C Supplements on Antioxidant Defence and Stress Proteins in Human Lymphocytes and Skeletal MuscleThe Journal of Physiology, 2003
- Determinants of Maximal Oxygen Transport and UtilizationAnnual Review of Physiology, 1996
- Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in Drosophila melanogasterScience, 1994
- Muscle damage during exercise: possible role of free radicals and protective effect of vitamin EProceedings Of The Nutrition Society, 1987
- Free radicals and tissue damage produced by exerciseBiochemical and Biophysical Research Communications, 1982
- Free Radicals in Biological MaterialsNature, 1954